Desmoglein-1, differentiation, and disease

Christoph M. Hammers*, John R. Stanley

*Corresponding author for this work
26 Citations (Scopus)


Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al. elucidate how the binding of the DSG1 cytoplasmic tail to the scaffolding protein Erbin decreases signaling through the Ras-Raf pathway to promote stratification and differentiation of keratinocytes in the epidermis.

Original languageEnglish
JournalJournal of Clinical Investigation
Issue number4
Pages (from-to)1419-1422
Number of pages4
Publication statusPublished - 01.04.2013

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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