Design und Rationale der HANSE-Studie: Eine ganzheitliche deutsche Lungenkrebs-Fröherkennungs-Studie unter Verwendung von Niedrigdosis-Computertomografie

Translated title of the contribution: Design and Rationale of the HANSE Study: A Holistic German Lung Cancer Screening Trial Using Low-Dose Computed Tomography

Jens Vogel-Claussen*, Florian Lasch, Benjamin Alexander Bollmann, Katharina May, Alexander Kuhlmann, Gerald Schmid-Bindert, Rudolf Kaaks, Jörg Barkhausen, Sabine Bohnet, Martin Reck

*Corresponding author for this work
3 Citations (Scopus)

Abstract

Background Despite the high prevalence and mortality of lung cancer and proven effectiveness of low-dose computed tomography (LDCT) to reduce mortality, Germany still lacks a national screening program. The German Institute for Quality and Efficiency in Health Care (IQWiG) and the Federal Office for Radiation Protection (BfS) both published positive scientific evaluations recommending a quality-controlled national screening program. IQWiG underlined the importance of a clear risk definition, integrated smoking cessation programs, and quality assurance, highlighting the necessity of procedural optimization. Methods and Objectives In the HANSE study, former and current smokers aged 55-79 years are assessed for their lung cancer risk by the NELSON and PLCO M2012risk scores. 5000 high-risk participants, defined as PLCO M20126-year risk ≥â Š1.58â Š% or fulfilling NELSON risk inclusion criteria, will be screened by LDCT at baseline and after 12 months. Lung nodules are analyzed by a modified Lung-RADS 1.1 score of the HANSE study, and values of emphysema and coronary calcium are determined and randomly reported to the participants. 7100 low-risk participants serve as a control. All patients are followed-up for up to 10 years. The sensitivity and specificity of the two risk assessments and LDCT screening, effects of the randomized LDCT reporting, efficiency of lung nodule management, and several other factors are assessed to analyze the success and quality of the holistic screening program. Conclusion The HANSE study is designed as a holistic lung cancer screening study in northern Germany to answer pressing questions for a successful implementation of an effective German lung cancer screening program. Key Points: HANSE is designed to address pressing questions for the implementation of lung cancer screening in Germany. HANSE compares NELSON and PLCO M2012risk assessments for optimal definition of the high-risk group.â Š HANSE integrates cardiac calcium and pulmonary emphysema scoring in a holistic screening approach. Citation Format Vogel-Claussen J, Lasch F, Bollmann B etâ Šal. Design and Rationale of the HANSE Study: A Holistic German Lung Cancer Screening Trial Using Low-Dose Computed Tomography. Fortschr Röntgenstr 2022; 194: 1333â Š-â Š1345.

Translated title of the contributionDesign and Rationale of the HANSE Study: A Holistic German Lung Cancer Screening Trial Using Low-Dose Computed Tomography
Original languageGerman
JournalRoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren
Volume194
Issue number12
Pages (from-to)1333-1345
Number of pages13
ISSN1438-9029
DOIs
Publication statusPublished - 12.2022

Research Areas and Centers

  • Academic Focus: Biomedical Engineering
  • Research Area: Luebeck Integrated Oncology Network (LION)
  • Centers: University Cancer Center Schleswig-Holstein (UCCSH)

DFG Research Classification Scheme

  • 205-30 Radiology, Nuclear Medicine, Radiation Therapy and Radiobiology
  • 205-32 Medical Physics, Biomedical Engineering
  • 205-13 Pneumology, Thoracal Surgery

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