Der weg in die zukunft: In-vivo-pathologie durch laserscan-mikroskopie

Microscopy of histological sections is the gold standard for the assessment of pathological tissue changes. Its disadvantages are invasiveness, the limited field of examination, and a certain time lag between the initial procedure, i.e. when the sample is taken, and the actual diagnosis. Some current research is dedicated to procedures to improve the intraoperative diagnosis, reduce the number of biopsies, or at least allow a more targeted collection of tissue samples. In particular, in vivo microscopy is being investigated for the histology-like imaging of superficial tissues. Clinical results with skin, colon and other tissues are promising, although in vivo microscopy has still not become a standard diagnostic procedure. The technology is still complex and expensive. In addition, only limited areas can by visualized in an acceptable time. However, it is expected that in vivo microscopy, possibly in conjunction with fluorescence diagnosis and optical coherence tomography, will find applications in gynecology in the future.