Der Stellenwert der Strahlentherapie bei symptomatischen Wirbelkörperhämangiomen (sWKH)

Translated title of the contribution: The significance of radiation therapy for symptomatic vertebral hemangiomas (SVH)

Reinhard Heyd*, M. Heinrich Seegenschmiedt, Dirk Rades, Cornelia Winkler, Hans T. Eich, Frank Bruns, Georg Gosheger, Normann Willich, Oliver Micke

*Corresponding author for this work
6 Citations (Scopus)


Purpose: To evaluate the efficacy of radiation therapy (RT) for symptomatic vertebral hemangioma (SVH). Material and Methods: Based on the Registry for Rare Benign Disorders (RRBD) of the German Cooperative Group on Radiation Therapy for Benign Diseases (GCG-BD), the clinical information, treatment plans and outcome data from seven cooperating German RT institutions were analyzed retrospectively. Results: Over a period of 39 years (1969-2008), a total of 84 patients with 96 symptomatic lesions underwent RT. The predominant indication was pain in 97.6%, and, in addition, 28.6% of patients had neurological deficits. The median total dose was 34 Gy (4.5-45 Gy), and the median single dose 2.0 Gy (0.5-3.0 Gy). After a median follow-up of 68 months (6-422 months), complete symptom relief (CR) occurred in 61.9% of patients, 28.6% had partial relief, and 9.5% had no relief (NR). The overall response rate (CR + PR) was 90.5%. In 26.2% of patients, radiologic signs of remineralization were noted. After a median follow-up of 70 months (8-124 months), symptom progression occurred in eight patients (9.5%). Therefore, the long-term rate of local control was 80.9%. Multivariate statistical analysis revealed a significantly higher rate of symptom relief and local control for total doses ≥ 34 Gy. Side effects > RTOG/EORTC grade 2 were not observed. Conclusion: RT is a safe and effective for treatment of SVH. Total doses of at least 34 Gy are recommended to achieve optimal treatment response.

Translated title of the contributionThe significance of radiation therapy for symptomatic vertebral hemangiomas (SVH)
Original languageGerman
JournalStrahlentherapie und Onkologie
Issue number8
Pages (from-to)430-435
Number of pages6
Publication statusPublished - 08.2010


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