Der ER - Mitochondrien - Kalzium - Zyklus und Organellfehlfunktion in der Pathophysiologie der Amyotrophen Lateralsklerose

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. Although the etiology remains unclear, disturbances in calcium homeostasis and protein folding are essential features of neurodegeneration in this disorder. Here, we review recent research findings on the interaction between endoplasmic reticulum (ER) and mitochondria, and its effect on calcium signaling and oxidative stress. We further provide insights into studies showing evidence that structures of the ER mitochondria calcium cycle (ERMCC) serve as a promising target for therapeutic approaches for treatment of ALS.