Der ER - Mitochondrien - Kalzium - Zyklus und Organellfehlfunktion in der Pathophysiologie der Amyotrophen Lateralsklerose

Translated title of the contribution: The ER Mitochondria Calcium Cycle and Organelle Dysfunction in the Pathophysiology of Amyotrophic Lateral Sclerosis

V. Tadic, T. T. Le, N. Goldhammer, J. Grosskreutz*

*Corresponding author for this work

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. Although the etiology remains unclear, disturbances in calcium homeostasis and protein folding are essential features of neurodegeneration in this disorder. Here, we review recent research findings on the interaction between endoplasmic reticulum (ER) and mitochondria, and its effect on calcium signaling and oxidative stress. We further provide insights into studies showing evidence that structures of the ER mitochondria calcium cycle (ERMCC) serve as a promising target for therapeutic approaches for treatment of ALS.

Translated title of the contributionThe ER Mitochondria Calcium Cycle and Organelle Dysfunction in the Pathophysiology of Amyotrophic Lateral Sclerosis
Original languageGerman
JournalKlinische Neurophysiologie
Volume46
Issue number4
Pages (from-to)190-196
Number of pages7
ISSN1434-0275
DOIs
Publication statusPublished - 01.12.2015
Externally publishedYes

Research Areas and Centers

  • Centers: Center for Neuromuscular Diseases

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