Der einsatz von TNFα-antagonisten bei primär systemischen vaskulitiden

Translated title of the contribution: Treatment of primary systemic vasculitis with TNFα-antagonists

Angela Gause*, Olga Arbach, Peter Lamprecht

*Corresponding author for this work
15 Citations (Scopus)


After the introduction of the TNFα blocking drugs Etanercept and Infliximab for the standard therapy of rheumatoid arthritis these effective substances have also been used successfully in many patients with primary systemic vasculitides, who were unresponsive to standard therapy. From pathophysiologic findings their use is justified by the prominent role of TNFα in the inflammation of small and large vessels. So far only open studies with a maximum of 20 patients and case reports are published. In summary there are reports of the successful treatment of 7 patients with rheumatoid vasculitis, 39 patients with Wegener's granulomatosis, 3 patients each with microscopic Polyangiitis, and 5 patients each with temporal Arteritis or Takayasu disease with Etanercept as well as with Infliximab. In addition, Infliximab was also used with a good response in severe Polymyalgia rheumatica in 4 cases and in one case of a cryoglobulinemic vasculitis. More than 60 patients with Panuveitis and other manifestations of Behçet's disease were treated with Infliximab or Etanercept according to preliminary reports. Because of the overall positive reports with TNFα collected in this review controlled investigations for their use in primary systemic vasculitis are necessary.

Translated title of the contributionTreatment of primary systemic vasculitis with TNFα-antagonists
Original languageGerman
JournalZeitschrift fur Rheumatologie
Issue number3
Pages (from-to)228-234
Number of pages7
Publication statusPublished - 06.2003

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


Dive into the research topics of 'Treatment of primary systemic vasculitis with TNFα-antagonists'. Together they form a unique fingerprint.

Cite this