Der Beitrag der Gene beim Parkinson-Syndrom

Katja Lohmann

doi:10.1007/s12268-015-0632-5

Der Beitrag der Gene beim Parkinson-Syndrom

Translated title of the contribution: The contribution of genes in Parkinson's disease

Katja Lohmann^*

^*Corresponding author for this work

Clinic of Neurology

Abstract

In the past two decades, a number of genetic causes of Parkinson disease (PD) have been elucidated. This includes both monogenic forms in which a single mutation is sufficient to cause PD and genetic risk factors. The latter only increase the susceptibility for PD and additional, likely environmental hits are necessary to develop the disease. PD genes such as LRRK2 and Parkin often encode proteins involved in mitochondrial function, protein degradation, or response to oxidative stress.

Translated title of the contribution	The contribution of genes in Parkinson's disease
Original language	German
Journal	BioSpektrum
Volume	21
Issue number	7
Pages (from-to)	699-702
Number of pages	4
ISSN	0947-0867
DOIs	https://doi.org/10.1007/s12268-015-0632-5
Publication status	Published - 01.01.2015

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10.1007/s12268-015-0632-5

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abstract = "In the past two decades, a number of genetic causes of Parkinson disease (PD) have been elucidated. This includes both monogenic forms in which a single mutation is sufficient to cause PD and genetic risk factors. The latter only increase the susceptibility for PD and additional, likely environmental hits are necessary to develop the disease. PD genes such as LRRK2 and Parkin often encode proteins involved in mitochondrial function, protein degradation, or response to oxidative stress.",

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AB - In the past two decades, a number of genetic causes of Parkinson disease (PD) have been elucidated. This includes both monogenic forms in which a single mutation is sufficient to cause PD and genetic risk factors. The latter only increase the susceptibility for PD and additional, likely environmental hits are necessary to develop the disease. PD genes such as LRRK2 and Parkin often encode proteins involved in mitochondrial function, protein degradation, or response to oxidative stress.

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Der Beitrag der Gene beim Parkinson-Syndrom

Abstract

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