TY - JOUR
T1 - Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus
AU - Kahl, Kai G.
AU - Schweiger, Ulrich
AU - Correll, Christoph
AU - Müller, Conrad
AU - Busch, Marie Luise
AU - Bauer, Michael
AU - Schwarz, Peter
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Background: Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression. Methods: We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM-IV. Results: Of 260 consecutively screened subjects, 150 (56.9 ± 8.1 years old, males = 56.7%, BMI = 27.2 ± 4.1 kg/m2) were at-risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity. Conclusions: Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM. We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for type 2 diabetes mellitus (T2DM). Of 260 screened patients, 150 were included. The metabolic syndrome was present in 27% of males and 25% of females, and was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM.
AB - Background: Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression. Methods: We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM-IV. Results: Of 260 consecutively screened subjects, 150 (56.9 ± 8.1 years old, males = 56.7%, BMI = 27.2 ± 4.1 kg/m2) were at-risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity. Conclusions: Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM. We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for type 2 diabetes mellitus (T2DM). Of 260 screened patients, 150 were included. The metabolic syndrome was present in 27% of males and 25% of females, and was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM.
UR - http://www.scopus.com/inward/record.url?scp=84925348532&partnerID=8YFLogxK
U2 - 10.1002/brb3.306
DO - 10.1002/brb3.306
M3 - Journal articles
C2 - 25642391
AN - SCOPUS:84925348532
VL - 5
SP - 7
JO - Brain and Behavior
JF - Brain and Behavior
SN - 2162-3279
IS - 3
ER -
