Dependence of germinal center B cells on expression of CD21/CD35 for survival

Michael B. Fischer; Siegfried Goerg; Li Ming Shen; Andrey P. Prodeus; Christopher C. Goodnow; Garnett Kelsoe; Michael C. Carroll

doi:10.1126/science.280.5363.582

Dependence of germinal center B cells on expression of CD21/CD35 for survival

Michael B. Fischer, Siegfried Goerg, Li Ming Shen, Andrey P. Prodeus, Christopher C. Goodnow, Garnett Kelsoe, Michael C. Carroll

Institute of Transfusion Medicin

Abstract

Affinity-driven selection of B lymphocytes within germinal centers is critical for the development of high-affinity memory cells and host protection. To investigate the role of the CD21/CD35 coreceptor in B cell competition for follicular retention and survival within the germinal center, either Cr2+ or Cr2null lysozyme-specific transgenic B cells were adoptively transferred into normal mice immunized with duck (DEL) or turkey (TEL) lysozyme, which bind with different affinities. In mice injected with high-affinity turkey lysozyme, Cr2null B cells responded by follicular retention; however, they could not survive within germinal centers. This suggests that CD21 provides a signal independent of antigen that is required for survival of B cells in the germinal center.

Original language	English
Title of host publication	Science
Number of pages	4
Publication date	24.04.1998
Pages	582-585
ISBN (Print)	0036-8075 (Print) 0036-8075 (Linking)
DOIs	https://doi.org/10.1126/science.280.5363.582
Publication status	Published - 24.04.1998

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AU - Goodnow, Christopher C.

AU - Kelsoe, Garnett

AU - Carroll, Michael C.

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Dependence of germinal center B cells on expression of CD21/CD35 for survival

Abstract

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