Dependence of germinal center B cells on expression of CD21/CD35 for survival

Michael B. Fischer, Siegfried Goerg, Li Ming Shen, Andrey P. Prodeus, Christopher C. Goodnow, Garnett Kelsoe, Michael C. Carroll


Affinity-driven selection of B lymphocytes within germinal centers is critical for the development of high-affinity memory cells and host protection. To investigate the role of the CD21/CD35 coreceptor in B cell competition for follicular retention and survival within the germinal center, either Cr2+ or Cr2null lysozyme-specific transgenic B cells were adoptively transferred into normal mice immunized with duck (DEL) or turkey (TEL) lysozyme, which bind with different affinities. In mice injected with high-affinity turkey lysozyme, Cr2null B cells responded by follicular retention; however, they could not survive within germinal centers. This suggests that CD21 provides a signal independent of antigen that is required for survival of B cells in the germinal center.
Original languageEnglish
Title of host publicationScience
Number of pages4
Publication date24.04.1998
ISBN (Print)0036-8075 (Print) 0036-8075 (Linking)
Publication statusPublished - 24.04.1998


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