Dependence of erythropoietin production on blood oxygen affinity and hemoglobin concentration in rats

W. Jelkmann, J. Seidl

14 Citations (Scopus)

Abstract

Plasma erythropoietin titers (Ep) were compared in rats subjected to different kinds of systemic hypoxia. Ep increased exponentially, when hypoxia was induced by exposure to simulated altitude (from <0.025 IU Ep/ml plasma at sea-level up to 3.65 IU EP/ml at 7000 m). An acute increase in the O2 affinity of blood augmented Ep production in normal rats but not in rats exposed to hypobaria. Ep also rose exponentially when isovolemic anemia was induced (e.g., 0.5 IU Ep/ml plasma were found at 7 g Hb/dl blood). When the same reduction in blood O2 carrying capacity was produced by CO-inhalation (0.1% CO in air), Ep increased to 5.57 IU/ml plasma. This very high value was considered to be partly due to the very high O2 affinity of carboxyhemoglobin. These results indicate that a left shift in the hemoglobin-O2 dissociation curve produces a stimulation of Ep production, particularly, when the O2-carrying capacity of blood is lowered.

Original languageEnglish
JournalBiomedica Biochimica Acta
Volume46
Issue number2-3
Pages (from-to)S304-S308
ISSN0232-766X
Publication statusPublished - 1987

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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