Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

Lea Järke; Saskia Weber-Stiehl; Kensuke Shima; Karlis Arturs Moors; Jerome Genth; Fenja Amrei Schuran; Lena Best; Markus Tschurtschenthaler; Burkhardt Flemer; Silke Lüschen; Christoph Röcken; Andreas Tholey; Christoph Kaleta; Jan Rupp; Philip Rosenstiel; Felix Sommer

doi:10.1002/cac2.70022

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

Lea Järke, Saskia Weber-Stiehl, Kensuke Shima, Karlis Arturs Moors, Jerome Genth, Fenja Amrei Schuran, Lena Best, Markus Tschurtschenthaler, Burkhardt Flemer, Silke Lüschen, Christoph Röcken, Andreas Tholey, Christoph Kaleta, Jan Rupp, Philip Rosenstiel, Felix Sommer^*

^*Corresponding author for this work

1 Citation (Scopus)

Original language	English
Journal	Cancer Communications
Volume	45
Issue number	7
Pages (from-to)	722-727
Number of pages	6
DOIs	https://doi.org/10.1002/cac2.70022
Publication status	Published - 07.2025

Funding

Funders	Funder number
Institute of Clinical Molecular Biology
Kiel University
Deutsche Forschungsgemeinschaft	EXS2167, SO1141/10‐1
medical faculty of Kiel University	F384430, K126408

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

2.21-05 Immunology

Access to Document

10.1002/cac2.70022

Cite this

Järke, L., Weber-Stiehl, S., Shima, K., Moors, K. A., Genth, J., Schuran, F. A., Best, L., Tschurtschenthaler, M., Flemer, B., Lüschen, S., Röcken, C., Tholey, A., Kaleta, C., Rupp, J., Rosenstiel, P., & Sommer, F. (2025). Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis. Cancer Communications, 45(7), 722-727. https://doi.org/10.1002/cac2.70022

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title = "Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis",

author = "Lea J{\"a}rke and Saskia Weber-Stiehl and Kensuke Shima and Moors, \{Karlis Arturs\} and Jerome Genth and Schuran, \{Fenja Amrei\} and Lena Best and Markus Tschurtschenthaler and Burkhardt Flemer and Silke L{\"u}schen and Christoph R{\"o}cken and Andreas Tholey and Christoph Kaleta and Jan Rupp and Philip Rosenstiel and Felix Sommer",

year = "2025",

month = jul,

doi = "10.1002/cac2.70022",

language = "English",

volume = "45",

pages = "722--727",

journal = "Cancer Communications",

issn = "2523-3548",

publisher = "American Association for the Advancement of Science",

number = "7",

}

Järke, L, Weber-Stiehl, S, Shima, K, Moors, KA, Genth, J, Schuran, FA, Best, L, Tschurtschenthaler, M, Flemer, B, Lüschen, S, Röcken, C, Tholey, A, Kaleta, C, Rupp, J, Rosenstiel, P & Sommer, F 2025, 'Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis', Cancer Communications, vol. 45, no. 7, pp. 722-727. https://doi.org/10.1002/cac2.70022

TY - JOUR

T1 - Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

AU - Järke, Lea

AU - Weber-Stiehl, Saskia

AU - Shima, Kensuke

AU - Moors, Karlis Arturs

AU - Genth, Jerome

AU - Schuran, Fenja Amrei

AU - Best, Lena

AU - Tschurtschenthaler, Markus

AU - Flemer, Burkhardt

AU - Lüschen, Silke

AU - Röcken, Christoph

AU - Tholey, Andreas

AU - Kaleta, Christoph

AU - Rupp, Jan

AU - Rosenstiel, Philip

AU - Sommer, Felix

PY - 2025/7

Y1 - 2025/7

UR - https://www.scopus.com/pages/publications/105000821093

UR - https://www.mendeley.com/catalogue/319243e3-6694-3c2d-9459-9da8fd405cc8/

U2 - 10.1002/cac2.70022

DO - 10.1002/cac2.70022

M3 - Comments/Debates

C2 - 40110992

AN - SCOPUS:105000821093

SN - 2523-3548

VL - 45

SP - 722

EP - 727

JO - Cancer Communications

JF - Cancer Communications

IS - 7

ER -

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

Funding

UN SDGs

Research Areas and Centers

DFG Research Classification Scheme

Access to Document

Other files and links

EXC 2167: Precision Medicine in Chronic Inflammation (PMI)

Cite this

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

Funding

UN SDGs

Research Areas and Centers

DFG Research Classification Scheme

Access to Document

Other files and links

Projects

EXC 2167: Precision Medicine in Chronic Inflammation (PMI)

Cite this