Delayed-onset dystonia due to perinatal asphyxia: A prospective study

Nataša Cerovac, Igor Petrović, Christine Klein, Vladimir S. Kostić*

*Corresponding author for this work
10 Citations (Scopus)


The objective of this work was to establish the existence and incidence of possible delayed-onset dystonia in a cohort of infants with diagnosed perinatal asphyxiai hypoxic-ischemic encephalopathy (HIE). This prospective study comprised 103 survivors of perinatal asphyxiai HIE, who were regularly followed and neurologically examined in the course of 7 to 13 years after birth (median 10 years). Neurological outcome at the end of the follow-up period was normal in 87 (84.5%) patients, while in 7 (6.8%) only mild neurological signs were detected (behavioral disturbances in 3, clumsiness in 2, and hypotonia in 1 patient). Severe cerebral palsy was diagnosed in nine patients (8.7%). Only one patient was diagnosed with possible delayed-onset segmental dystonia. At the age of 4 years he developed cervical dystonia with spread to one arm in the course of 1.5 years (segmental dystonia) and then stabilized. Other known causes of dystonia, including a DYT1 mutation, were excluded. Our preliminary data suggest that over the course of at least 7 years after birth, approximately 1% of infants who survived perinatal asphyxial HIE would develop delayed-onset dystonia.

Original languageEnglish
JournalMovement Disorders
Issue number16
Pages (from-to)2426-2429
Number of pages4
Publication statusPublished - 01.12.2007


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