Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis

Giuseppina Arbore; Voon H. Ong; Benedetta Costantini; Christopher P. Denton; David Abraham; Leo Placais; Kevin Blighe; Lynne Mitchell; Richard Ellis; Susanne Heck; Paola Nocerino; Trent M. Woodruff; Shahram Kordasti; Claudia Kemper; Dennis E. Hourcade

doi:10.1038/s41423-019-0360-8

Deep phenotyping detects a pathological CD4⁺ T-cell complosome signature in systemic sclerosis

Giuseppina Arbore, Voon H. Ong, Benedetta Costantini, Christopher P. Denton, David Abraham, Leo Placais, Kevin Blighe, Lynne Mitchell, Richard Ellis, Susanne Heck, Paola Nocerino, Trent M. Woodruff, Shahram Kordasti^*, Claudia Kemper, Dennis E. Hourcade

^*Corresponding author for this work

Institute of Systemic Inflammation Research

13 Citations (Scopus)

Original language	English
Journal	Cellular and Molecular Immunology
Volume	17
Issue number	9
Pages (from-to)	1010-1013
Number of pages	4
ISSN	1672-7681
DOIs	https://doi.org/10.1038/s41423-019-0360-8
Publication status	Published - 01.09.2020

Funding

We thank the patients and the healthy donors for their support. This work was financed by MRC Centre grant MR/J006742/1, an EU-funded Innovative Medicines Initiative BTCURE (C.K.), a Wellcome Trust Investigator Award (C.K.), the King’s Bioscience Institute at King’s College London (G.A.), The King’ College London BRC Genomics Facility, the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, National Institute Of Health grant R21 AI123789 (D.E.H.) and by the Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH (C.K.). D.E.H. and L.M. are grateful for the support of the Washington University School of Medicine Immunomonitoring Laboratory. V.H.O., C.P.D. and D.A. are grateful for funding support from Versus Arthritis, Scleroderma & Raynaud’s UK, Rosetrees Trust and Royal Free Charity. T.M.W. is supported by a National Health and Medical Research Council Fellowship (1105420). SK is supported by Cancer Research UK (CRUK). The authors acknowledge financial support from the Department of Health via the National Institute for Health Research (NIHR) Biomedical Research Center awarded to Guy’s & St Thomas’ NHS Foundation Trust in Partnership with King’s College London and King’s College Hospital NHS Foundation Trust.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

Access to Document

10.1038/s41423-019-0360-8

Cite this

Arbore, G., Ong, V. H., Costantini, B., Denton, C. P., Abraham, D., Placais, L., Blighe, K., Mitchell, L., Ellis, R., Heck, S., Nocerino, P., Woodruff, T. M., Kordasti, S., Kemper, C., & Hourcade, D. E. (2020). Deep phenotyping detects a pathological CD4⁺ T-cell complosome signature in systemic sclerosis. Cellular and Molecular Immunology, 17(9), 1010-1013. https://doi.org/10.1038/s41423-019-0360-8

@article{05fb4d7306d84f45adce24fbe2cd7aa2,

title = "Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis",

author = "Giuseppina Arbore and Ong, \{Voon H.\} and Benedetta Costantini and Denton, \{Christopher P.\} and David Abraham and Leo Placais and Kevin Blighe and Lynne Mitchell and Richard Ellis and Susanne Heck and Paola Nocerino and Woodruff, \{Trent M.\} and Shahram Kordasti and Claudia Kemper and Hourcade, \{Dennis E.\}",

note = "Funding Information: We thank the patients and the healthy donors for their support. This work was financed by MRC Centre grant MR/J006742/1, an EU-funded Innovative Medicines Initiative BTCURE (C.K.), a Wellcome Trust Investigator Award (C.K.), the King{\textquoteright}s Bioscience Institute at King{\textquoteright}s College London (G.A.), The King{\textquoteright} College London BRC Genomics Facility, the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust and King{\textquoteright}s College London, National Institute Of Health grant R21 AI123789 (D.E.H.) and by the Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH (C.K.). D.E.H. and L.M. are grateful for the support of the Washington University School of Medicine Immunomonitoring Laboratory. V.H.O., C.P.D. and D.A. are grateful for funding support from Versus Arthritis, Scleroderma \& Raynaud{\textquoteright}s UK, Rosetrees Trust and Royal Free Charity. T.M.W. is supported by a National Health and Medical Research Council Fellowship (1105420). SK is supported by Cancer Research UK (CRUK). The authors acknowledge financial support from the Department of Health via the National Institute for Health Research (NIHR) Biomedical Research Center awarded to Guy{\textquoteright}s \& St Thomas{\textquoteright} NHS Foundation Trust in Partnership with King{\textquoteright}s College London and King{\textquoteright}s College Hospital NHS Foundation Trust. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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Arbore, G, Ong, VH, Costantini, B, Denton, CP, Abraham, D, Placais, L, Blighe, K, Mitchell, L, Ellis, R, Heck, S, Nocerino, P, Woodruff, TM, Kordasti, S, Kemper, C & Hourcade, DE 2020, 'Deep phenotyping detects a pathological CD4⁺ T-cell complosome signature in systemic sclerosis', Cellular and Molecular Immunology, vol. 17, no. 9, pp. 1010-1013. https://doi.org/10.1038/s41423-019-0360-8

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T1 - Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis

AU - Arbore, Giuseppina

AU - Ong, Voon H.

AU - Costantini, Benedetta

AU - Denton, Christopher P.

AU - Abraham, David

AU - Placais, Leo

AU - Blighe, Kevin

AU - Mitchell, Lynne

AU - Ellis, Richard

AU - Heck, Susanne

AU - Nocerino, Paola

AU - Woodruff, Trent M.

AU - Kordasti, Shahram

AU - Kemper, Claudia

AU - Hourcade, Dennis E.

N1 - Funding Information: We thank the patients and the healthy donors for their support. This work was financed by MRC Centre grant MR/J006742/1, an EU-funded Innovative Medicines Initiative BTCURE (C.K.), a Wellcome Trust Investigator Award (C.K.), the King’s Bioscience Institute at King’s College London (G.A.), The King’ College London BRC Genomics Facility, the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, National Institute Of Health grant R21 AI123789 (D.E.H.) and by the Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH (C.K.). D.E.H. and L.M. are grateful for the support of the Washington University School of Medicine Immunomonitoring Laboratory. V.H.O., C.P.D. and D.A. are grateful for funding support from Versus Arthritis, Scleroderma & Raynaud’s UK, Rosetrees Trust and Royal Free Charity. T.M.W. is supported by a National Health and Medical Research Council Fellowship (1105420). SK is supported by Cancer Research UK (CRUK). The authors acknowledge financial support from the Department of Health via the National Institute for Health Research (NIHR) Biomedical Research Center awarded to Guy’s & St Thomas’ NHS Foundation Trust in Partnership with King’s College London and King’s College Hospital NHS Foundation Trust. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

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