TY - JOUR
T1 - Deep brain stimulation: Response to neuronal high frequency stimulation is mediated through GABAA receptor activation in rats
AU - Moser, Andreas
AU - Gieselberg, Annabella
AU - Ro, Bora
AU - Keller, Christine
AU - Qadri, Fatimunnisa
PY - 2003/4/24
Y1 - 2003/4/24
N2 - High frequency stimulation (HFS) of deep brain regions such as globus pallidus internus or subthalamic nucleus can reverse Parkinson's symptoms probably through activation of γ-aminobutyric acid (GABA)ergic neurotransmission. To prove the hypothesis, rat striatal slices were stimulated electrically (130 Hz) in vitro and dopamine (DA) outflow was measured using high performance liquid chromatography. HFS induced an attenuation in basal DA release in perfusate. Veratridine-induced DA outflow was blocked by the simultaneous application of HFS. Addition of bicuculline, a GABAA receptor antagonist, reversed the effect of HFS on DA outflow. In addition, destruction of striatal GABAergic neurons with kainic acid also reversed the effect of HFS. In conclusion, our present data provide strong evidence that HFS does not only need presynaptic GABAA receptors but also intact GABAergic nerve terminals coupled to GABAA receptors to exert an inhibitory effect and give a rationale of HFS effectiveness in the treatment of Parkinson's disease.
AB - High frequency stimulation (HFS) of deep brain regions such as globus pallidus internus or subthalamic nucleus can reverse Parkinson's symptoms probably through activation of γ-aminobutyric acid (GABA)ergic neurotransmission. To prove the hypothesis, rat striatal slices were stimulated electrically (130 Hz) in vitro and dopamine (DA) outflow was measured using high performance liquid chromatography. HFS induced an attenuation in basal DA release in perfusate. Veratridine-induced DA outflow was blocked by the simultaneous application of HFS. Addition of bicuculline, a GABAA receptor antagonist, reversed the effect of HFS on DA outflow. In addition, destruction of striatal GABAergic neurons with kainic acid also reversed the effect of HFS. In conclusion, our present data provide strong evidence that HFS does not only need presynaptic GABAA receptors but also intact GABAergic nerve terminals coupled to GABAA receptors to exert an inhibitory effect and give a rationale of HFS effectiveness in the treatment of Parkinson's disease.
UR - http://www.scopus.com/inward/record.url?scp=0037464393&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(03)00133-2
DO - 10.1016/S0304-3940(03)00133-2
M3 - Journal articles
C2 - 12676343
AN - SCOPUS:0037464393
SN - 0304-3940
VL - 341
SP - 57
EP - 60
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -
