Deep brain stimulation of nucleus accumbens region in alcoholism affects reward processing

Marcus Heldmann; Georg Berding; Jürgen Voges; Bernhard Bogerts; Imke Galazky; Ulf Müller; Gunther Baillot; Hans Jochen Heinze; Thomas F. Münte

doi:10.1371/journal.pone.0036572

Deep brain stimulation of nucleus accumbens region in alcoholism affects reward processing

Marcus Heldmann^*, Georg Berding, Jürgen Voges, Bernhard Bogerts, Imke Galazky, Ulf Müller, Gunther Baillot, Hans Jochen Heinze, Thomas F. Münte

^*Corresponding author for this work

Clinic of Neurology

26 Citations (Scopus)

Abstract

The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H₂[¹⁵O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. Behavioral data analysis revealed a less risky, more careful choice behavior under active DBS compared to DBS switched off. PET showed win- and loss-related activations in the paracingulate cortex, temporal poles, precuneus and hippocampus under active DBS, brain areas that have been implicated in action monitoring and behavioral control. Except for the temporal pole these activations were not seen when DBS was deactivated. These findings suggest that DBS of the NAcc may act partially by improving behavioral control.

Original language	English
Article number	e36572
Journal	PLoS ONE
Volume	7
Issue number	5
ISSN	1553-7390
DOIs	https://doi.org/10.1371/journal.pone.0036572
Publication status	Published - 22.05.2012

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abstract = "The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H2[15O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. Behavioral data analysis revealed a less risky, more careful choice behavior under active DBS compared to DBS switched off. PET showed win- and loss-related activations in the paracingulate cortex, temporal poles, precuneus and hippocampus under active DBS, brain areas that have been implicated in action monitoring and behavioral control. Except for the temporal pole these activations were not seen when DBS was deactivated. These findings suggest that DBS of the NAcc may act partially by improving behavioral control.",

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AU - Heldmann, Marcus

AU - Berding, Georg

AU - Voges, Jürgen

AU - Bogerts, Bernhard

AU - Galazky, Imke

AU - Müller, Ulf

AU - Baillot, Gunther

AU - Heinze, Hans Jochen

AU - Münte, Thomas F.

PY - 2012/5/22

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AB - The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H2[15O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. Behavioral data analysis revealed a less risky, more careful choice behavior under active DBS compared to DBS switched off. PET showed win- and loss-related activations in the paracingulate cortex, temporal poles, precuneus and hippocampus under active DBS, brain areas that have been implicated in action monitoring and behavioral control. Except for the temporal pole these activations were not seen when DBS was deactivated. These findings suggest that DBS of the NAcc may act partially by improving behavioral control.

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Deep brain stimulation of nucleus accumbens region in alcoholism affects reward processing

Abstract

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