TY - JOUR
T1 - Deep brain stimulation for dystonia: A novel perspective on the value of genetic testing
AU - Jinnah, H. A.
AU - Alterman, Ron
AU - Klein, Christine
AU - Krauss, Joachim K.
AU - Moro, Elena
AU - Vidailhet, Marie
AU - Raike, Robert
PY - 2017/4/1
Y1 - 2017/4/1
N2 - The dystonias are a group of disorders characterized by excessive muscle contractions leading to abnormal movements and postures. There are many different clinical manifestations and underlying causes. Deep brain stimulation (DBS) provides an effect treatment, but outcomes can vary considerably among the different subtypes of dystonia. Several variables are thought to contribute to this variation including age of onset and duration of dystonia, specific characteristics of the dystonic movements, location of stimulation and stimulator settings, and others. The potential contributions of genetic factors have received little attention. In this review, we summarize evidence that some of the variation in DBS outcomes for dystonia is due to genetic factors. The evidence suggests that more methodical genetic testing may provide useful information in the assessment of potential surgical candidates, and in advancing our understanding of the biological mechanisms that influence DBS outcomes.
AB - The dystonias are a group of disorders characterized by excessive muscle contractions leading to abnormal movements and postures. There are many different clinical manifestations and underlying causes. Deep brain stimulation (DBS) provides an effect treatment, but outcomes can vary considerably among the different subtypes of dystonia. Several variables are thought to contribute to this variation including age of onset and duration of dystonia, specific characteristics of the dystonic movements, location of stimulation and stimulator settings, and others. The potential contributions of genetic factors have received little attention. In this review, we summarize evidence that some of the variation in DBS outcomes for dystonia is due to genetic factors. The evidence suggests that more methodical genetic testing may provide useful information in the assessment of potential surgical candidates, and in advancing our understanding of the biological mechanisms that influence DBS outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85011711441&partnerID=8YFLogxK
U2 - 10.1007/s00702-016-1656-9
DO - 10.1007/s00702-016-1656-9
M3 - Scientific review articles
C2 - 28160152
AN - SCOPUS:85011711441
SN - 0300-9564
VL - 124
SP - 417
EP - 430
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 4
ER -