Deep brain stimulation and synchronous neurotransmitter detection

M.G. Litza, A Hiller, Andreas Moser, Ulrich Hofmann


The goal of this work was to develop a method for time and position simultaneous deep brain stimulation (DBS) and neurotransmitter detection in an in vivo animal model. A simple chronic implant has been designed uniting both existing microdialysis probes and concentric microelectrodes for high frequency electrical stimulation (HFS). This implant enables HFS and microdialysis in one animal at the same time and at the same brain position. The method has been tested in vivo and samples of dialysate were analysed offline by HPLC and ECD. The detection of neurotransmitters in these samples was successful. While biochemical effects of HFS are still unknown, our method aims to answer this open questions.
Original languageEnglish
JournalBiomedizinische Technik
Pages (from-to)509-510
Number of pages2
Publication statusPublished - 01.01.2005


Dive into the research topics of 'Deep brain stimulation and synchronous neurotransmitter detection'. Together they form a unique fingerprint.

Cite this