The goal of this work was to develop a method for time and position simultaneous deep brain stimulation (DBS) and neurotransmitter detection in an in vivo animal model. A simple chronic implant has been designed uniting both existing microdialysis probes and concentric microelectrodes for high frequency electrical stimulation (HFS). This implant enables HFS and microdialysis in one animal at the same time and at the same brain position. The method has been tested in vivo and samples of dialysate were analysed offline by HPLC and ECD. The detection of neurotransmitters in these samples was successful. While biochemical effects of HFS are still unknown, our method aims to answer this open questions.
|Number of pages||2|
|Publication status||Published - 01.01.2005|