TY - JOUR
T1 - Dare to compare. Development of atherosclerotic lesions in human, mouse, and zebrafish
AU - Vedder, Viviana L.
AU - Aherrahrou, Zouhair
AU - Erdmann, Jeanette
PY - 2020/6/30
Y1 - 2020/6/30
N2 - Cardiovascular diseases, such as atherosclerosis, are the leading cause of death worldwide. Although mice are currently the most commonly used model for atherosclerosis, zebrafish are emerging as an alternative, especially for inflammatory and lipid metabolism studies. Here, we review the history of in vivo atherosclerosis models and highlight the potential for future studies on inflammatory responses in lipid deposits in zebrafish, based on known immune reactions in humans and mice, in anticipation of new zebrafish models with more advanced atherosclerotic plaques.
AB - Cardiovascular diseases, such as atherosclerosis, are the leading cause of death worldwide. Although mice are currently the most commonly used model for atherosclerosis, zebrafish are emerging as an alternative, especially for inflammatory and lipid metabolism studies. Here, we review the history of in vivo atherosclerosis models and highlight the potential for future studies on inflammatory responses in lipid deposits in zebrafish, based on known immune reactions in humans and mice, in anticipation of new zebrafish models with more advanced atherosclerotic plaques.
UR - http://www.scopus.com/inward/record.url?scp=85092687593&partnerID=8YFLogxK
U2 - 10.3389/fcvm.2020.00109
DO - 10.3389/fcvm.2020.00109
M3 - Scientific review articles
AN - SCOPUS:85092687593
SN - 2297-055X
VL - 7
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 109
ER -
