TY - JOUR
T1 - Cytokines in head and neck cancer
AU - Pries, Ralph
AU - Wollenberg, Barbara
N1 - Funding Information:
The authors would like to acknowledge and thank the following funding bodies: Mildred Scheel-Stiftung (Deutsche Krebshilfe), the Monika Kutzner Stiftung, the Werner and Klara Kreitz Stiftung, and the Rudolf Bartling Stiftung.
PY - 2006/6
Y1 - 2006/6
N2 - Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers in the world. Standard treatment has only marginally improved the 5-year survival rate of patients with HNSCC in the last 40 years. Alterations in immune, inflammatory as well as angiogenetic responses within the HNSCC microenvironment play a critical role in tumor aggressiveness and its response to chemo- and radiation therapies as well as its influence on the immune system. Therefore, the better understanding of secretion and regulation pathways of immune suppressive and proangiogenic cytokines in HNSCC is essential to increase the clinical perspective of this tumor type with respect to an immunomodulatory intervention in patients with HNSCC.
AB - Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers in the world. Standard treatment has only marginally improved the 5-year survival rate of patients with HNSCC in the last 40 years. Alterations in immune, inflammatory as well as angiogenetic responses within the HNSCC microenvironment play a critical role in tumor aggressiveness and its response to chemo- and radiation therapies as well as its influence on the immune system. Therefore, the better understanding of secretion and regulation pathways of immune suppressive and proangiogenic cytokines in HNSCC is essential to increase the clinical perspective of this tumor type with respect to an immunomodulatory intervention in patients with HNSCC.
UR - http://www.scopus.com/inward/record.url?scp=33745432758&partnerID=8YFLogxK
U2 - 10.1016/j.cytogfr.2006.02.001
DO - 10.1016/j.cytogfr.2006.02.001
M3 - Short survey
C2 - 16540364
AN - SCOPUS:33745432758
SN - 1359-6101
VL - 17
SP - 141
EP - 146
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
IS - 3
ER -
