Cytokines in head and neck cancer

Ralph Pries, Barbara Wollenberg*

*Corresponding author for this work
97 Citations (Scopus)


Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers in the world. Standard treatment has only marginally improved the 5-year survival rate of patients with HNSCC in the last 40 years. Alterations in immune, inflammatory as well as angiogenetic responses within the HNSCC microenvironment play a critical role in tumor aggressiveness and its response to chemo- and radiation therapies as well as its influence on the immune system. Therefore, the better understanding of secretion and regulation pathways of immune suppressive and proangiogenic cytokines in HNSCC is essential to increase the clinical perspective of this tumor type with respect to an immunomodulatory intervention in patients with HNSCC.

Original languageEnglish
JournalCytokine and Growth Factor Reviews
Issue number3
Pages (from-to)141-146
Number of pages6
Publication statusPublished - 06.2006


Dive into the research topics of 'Cytokines in head and neck cancer'. Together they form a unique fingerprint.

Cite this