Cytokine release of human NK cells solely triggered with Poly I: C

Sandra Wulff; Ralph Pries; Barbara Wollenberg

doi:10.1016/j.cellimm.2010.03.020

Cytokine release of human NK cells solely triggered with Poly I: C

Sandra Wulff, Ralph Pries, Barbara Wollenberg^*

^*Corresponding author for this work

10 Citations (Scopus)

Abstract

Natural killer (NK) cells play a crucial role in innate immunity as effectors against tumor cells and pathogen-infected cells. Our data show for the first time that NK cells produce high levels of cytokines interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in response to stimulation with the artificial RNA analogue Poly I:C without additional cytokines or contact to other types of immune cells. An incubation period of 48. h is necessary to induce cytokine release by Poly I:C. These data suggest Poly I:C as a competent direct activator and immunomodulator of NK cell functions.

Original language	English
Journal	Cellular Immunology
Volume	263
Issue number	2
Pages (from-to)	135-137
Number of pages	3
ISSN	0008-8749
DOIs	https://doi.org/10.1016/j.cellimm.2010.03.020
Publication status	Published - 16.06.2010

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abstract = "Natural killer (NK) cells play a crucial role in innate immunity as effectors against tumor cells and pathogen-infected cells. Our data show for the first time that NK cells produce high levels of cytokines interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in response to stimulation with the artificial RNA analogue Poly I:C without additional cytokines or contact to other types of immune cells. An incubation period of 48. h is necessary to induce cytokine release by Poly I:C. These data suggest Poly I:C as a competent direct activator and immunomodulator of NK cell functions.",

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N2 - Natural killer (NK) cells play a crucial role in innate immunity as effectors against tumor cells and pathogen-infected cells. Our data show for the first time that NK cells produce high levels of cytokines interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in response to stimulation with the artificial RNA analogue Poly I:C without additional cytokines or contact to other types of immune cells. An incubation period of 48. h is necessary to induce cytokine release by Poly I:C. These data suggest Poly I:C as a competent direct activator and immunomodulator of NK cell functions.

AB - Natural killer (NK) cells play a crucial role in innate immunity as effectors against tumor cells and pathogen-infected cells. Our data show for the first time that NK cells produce high levels of cytokines interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in response to stimulation with the artificial RNA analogue Poly I:C without additional cytokines or contact to other types of immune cells. An incubation period of 48. h is necessary to induce cytokine release by Poly I:C. These data suggest Poly I:C as a competent direct activator and immunomodulator of NK cell functions.

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Cytokine release of human NK cells solely triggered with Poly I: C

Abstract

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