Cycloisomerization of dienes and enynes catalysed by a modified ruthenium carbene species

Álvaro Mallagaray; Kazem Mohammadiannejad-Abbasabadi; Sandra Medina; Gema Domínguez; Javier Pérez-Castells

doi:10.1039/c2ob07185a

Cycloisomerization of dienes and enynes catalysed by a modified ruthenium carbene species

Álvaro Mallagaray, Kazem Mohammadiannejad-Abbasabadi, Sandra Medina, Gema Domínguez, Javier Pérez-Castells^*

^*Corresponding author for this work

Institute of Chemistry and Metabolomics

19 Citations (Scopus)

Abstract

Cycloisomerization is a totally atom economic procedure which converts dienes and enynes into cyclic molecules. Modification of Grubbs' 2nd generation catalysts by reaction with dimethylformamide provides a new species able to catalyse this transformation. Selection of suitable conditions allowed high yields and selectivity. Studies performed in order to identify the catalytic species point to a non-carbenic ruthenium complex that has lost the phosphine. No hydride signals appeared. In addition, the reaction works with enynes and the new species catalyses efficiently crossed cyclotrimerizations of alkynes with diynes.

Original language	English
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	33
Pages (from-to)	6665-6672
Number of pages	8
ISSN	1477-0520
DOIs	https://doi.org/10.1039/c2ob07185a
Publication status	Published - 07.09.2012

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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abstract = "Cycloisomerization is a totally atom economic procedure which converts dienes and enynes into cyclic molecules. Modification of Grubbs' 2nd generation catalysts by reaction with dimethylformamide provides a new species able to catalyse this transformation. Selection of suitable conditions allowed high yields and selectivity. Studies performed in order to identify the catalytic species point to a non-carbenic ruthenium complex that has lost the phosphine. No hydride signals appeared. In addition, the reaction works with enynes and the new species catalyses efficiently crossed cyclotrimerizations of alkynes with diynes.",

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T1 - Cycloisomerization of dienes and enynes catalysed by a modified ruthenium carbene species

AU - Mallagaray, Álvaro

AU - Mohammadiannejad-Abbasabadi, Kazem

AU - Medina, Sandra

AU - Domínguez, Gema

AU - Pérez-Castells, Javier

PY - 2012/9/7

Y1 - 2012/9/7

N2 - Cycloisomerization is a totally atom economic procedure which converts dienes and enynes into cyclic molecules. Modification of Grubbs' 2nd generation catalysts by reaction with dimethylformamide provides a new species able to catalyse this transformation. Selection of suitable conditions allowed high yields and selectivity. Studies performed in order to identify the catalytic species point to a non-carbenic ruthenium complex that has lost the phosphine. No hydride signals appeared. In addition, the reaction works with enynes and the new species catalyses efficiently crossed cyclotrimerizations of alkynes with diynes.

AB - Cycloisomerization is a totally atom economic procedure which converts dienes and enynes into cyclic molecules. Modification of Grubbs' 2nd generation catalysts by reaction with dimethylformamide provides a new species able to catalyse this transformation. Selection of suitable conditions allowed high yields and selectivity. Studies performed in order to identify the catalytic species point to a non-carbenic ruthenium complex that has lost the phosphine. No hydride signals appeared. In addition, the reaction works with enynes and the new species catalyses efficiently crossed cyclotrimerizations of alkynes with diynes.

UR - https://www.scopus.com/pages/publications/84864630019

U2 - 10.1039/c2ob07185a

DO - 10.1039/c2ob07185a

M3 - Journal articles

AN - SCOPUS:84864630019

SN - 1477-0520

VL - 10

SP - 6665

EP - 6672

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 33

ER -

Cycloisomerization of dienes and enynes catalysed by a modified ruthenium carbene species

Abstract

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