Cycloisomerization of dienes and enynes catalysed by a modified ruthenium carbene species

Álvaro Mallagaray, Kazem Mohammadiannejad-Abbasabadi, Sandra Medina, Gema Domínguez, Javier Pérez-Castells*

*Corresponding author for this work
18 Citations (Scopus)


Cycloisomerization is a totally atom economic procedure which converts dienes and enynes into cyclic molecules. Modification of Grubbs' 2nd generation catalysts by reaction with dimethylformamide provides a new species able to catalyse this transformation. Selection of suitable conditions allowed high yields and selectivity. Studies performed in order to identify the catalytic species point to a non-carbenic ruthenium complex that has lost the phosphine. No hydride signals appeared. In addition, the reaction works with enynes and the new species catalyses efficiently crossed cyclotrimerizations of alkynes with diynes.

Original languageEnglish
JournalOrganic and Biomolecular Chemistry
Issue number33
Pages (from-to)6665-6672
Number of pages8
Publication statusPublished - 07.09.2012

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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