Cutting edge: Neutrophil granulocyte serves as a vector for Leishmania entry into macrophages

Ger Van Zandbergen*, Matthias Klinger, Antje Mueller, Sonja Dannenberg, Andreas Gebert, Werner Solbach, Tamás Laskay

*Corresponding author for this work
250 Citations (Scopus)


Macrophages (MF) are the final host cells for multiplication of the intracellular parasite Leishmania major (L. major). However, polymorphonuclear neutrophil granulocytes (PMN), not MF, are the first leukocytes that migrate to the site of infection and encounter the parasites. Our previous studies indicated that PMN phagocytose but do not kill L. major. Upon infection with Leishmania, apoptosis of human PMN is delayed and takes 2 days to occur. Infected PMN were found to secrete high levels of the chemokine MIP-1β, which attracts MF. In this study, we investigated whether MF can ingest parasite-infected PMN. We observed that MF readily phagocytosed infected apoptotic PMN. Leishmania internalized by this indirect way survived and multiplied in MF. Moreover, ingestion of apoptotic infected PMN resulted in release of the antiinflammatory cytokine TGF-β by MF. These data indicate that Leishmania can misuse granulocytes as a "Trojan horse" to enter their final host cells "silently" and unrecognized.

Original languageEnglish
JournalJournal of Immunology
Issue number11
Pages (from-to)6521-6525
Number of pages5
Publication statusPublished - 01.12.2004

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


Dive into the research topics of 'Cutting edge: Neutrophil granulocyte serves as a vector for Leishmania entry into macrophages'. Together they form a unique fingerprint.

Cite this