Cutaneous leishmaniasis in south-western Ethiopia: Ocholo revisited

Genene Mengistu; Tamas Laskay; Teferi Gemetchu; David Humber; Mulugetta Ersamo; David Evans; Hailu Teferedegn; Marie Anne Phelouzat; Dominique Frommel

doi:10.1016/0035-9203(92)90546-O

Cutaneous leishmaniasis in south-western Ethiopia: Ocholo revisited

Genene Mengistu, Tamas Laskay, Teferi Gemetchu, David Humber, Mulugetta Ersamo, David Evans, Hailu Teferedegn, Marie Anne Phelouzat, Dominique Frommel^*

^*Corresponding author for this work

Institute of Medical Microbiology

44 Citations (Scopus)

Abstract

The borough of Ocholo, on the western side of the Ethiopian Rift Valley, is an endemic focus for Leishmania aethiopica infection and has been surveyed thrice between 1987 and 1990. In 1989, 3022 inhabitants (>95% of the population) were interviewed and examined. The overall prevalence of localized cutaneous leishmaniasis (LCL) was 3.6-4.0%, with a peak value of 8.5% in the 0-10 years old age group. In half of the patients the active disease was estimated to last for 9.6±6 months; in 10%, it exceeded 3 years. Scars of LCL were present in 34.3% of the residents. Leishmanin skin tests were positive in 54% of 120 school-children without signs of the disease. Therefore, in Ocholo a minimum of 71.6% of the population has been exposed to L. aethiopica infection. Two cases of the diffuse form of cutaneous leishmaniasis were observed. In this highland biotope, Phlebotomus pedifer was found to be the major, and possibly the only, vector for L. aethiopica.

Original language	English
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	86
Issue number	2
Pages (from-to)	149-153
Number of pages	5
ISSN	0035-9203
DOIs	https://doi.org/10.1016/0035-9203(92)90546-O
Publication status	Published - 01.01.1992

Funding

Acknowledeements We areg ratefutl o the Ministry of Healtho f Ethiopiaf or con-sentt o performt his study,t o Dr H. Akuffo for sharingu nvub-lished data with us, to the medicalp ersonneol f thexhencha Hospitala nd of the HealthC entrea t Ocholof or theirh elp, and to the WHOiTDR LeishmaniaU nit for supplyingl eishmanin preparationsW. e alsot hankt heC atholicM ission,C henchaf,o r their warm hospitality, Drs T. Ayele, S. Britton and K. McGinnes for discussiono f findings, Mrs GenetT adessea nd Mr AlemayehuK ifle for assistancien field andl aboratoryw ork, andM rs MuluneshN egashf or preparingth et ypescript. AHN is associatewd ith theA ll-Africa Leprosya nd Rehabilitation Training Centre( ALERT), Addis Ababa,a nd supportedb y theN orwegiana nd SwedishA genciesfo r InternationaDl evelop-ment( NORAD and SIDA). D. F. is a staffm embero f the Institut National de la Santee t de la RechercheM edicale(INSERM), Paris, secondedto AHRI; G. M. receivedfi nancials upportf rom SAREC, Stockholm; and the Fondation pour le Progrts de l’Homme,P aris,s ubsidizedo nej ourneyb y D.F.

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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@article{e9ea2d7fc733492b9e7bc1e75c918aa4,

title = "Cutaneous leishmaniasis in south-western Ethiopia: Ocholo revisited",

abstract = "The borough of Ocholo, on the western side of the Ethiopian Rift Valley, is an endemic focus for Leishmania aethiopica infection and has been surveyed thrice between 1987 and 1990. In 1989, 3022 inhabitants (>95\% of the population) were interviewed and examined. The overall prevalence of localized cutaneous leishmaniasis (LCL) was 3.6-4.0\%, with a peak value of 8.5\% in the 0-10 years old age group. In half of the patients the active disease was estimated to last for 9.6±6 months; in 10\%, it exceeded 3 years. Scars of LCL were present in 34.3\% of the residents. Leishmanin skin tests were positive in 54\% of 120 school-children without signs of the disease. Therefore, in Ocholo a minimum of 71.6\% of the population has been exposed to L. aethiopica infection. Two cases of the diffuse form of cutaneous leishmaniasis were observed. In this highland biotope, Phlebotomus pedifer was found to be the major, and possibly the only, vector for L. aethiopica.",

author = "Genene Mengistu and Tamas Laskay and Teferi Gemetchu and David Humber and Mulugetta Ersamo and David Evans and Hailu Teferedegn and Phelouzat, \{Marie Anne\} and Dominique Frommel",

year = "1992",

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doi = "10.1016/0035-9203(92)90546-O",

language = "English",

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T1 - Cutaneous leishmaniasis in south-western Ethiopia

T2 - Ocholo revisited

AU - Mengistu, Genene

AU - Laskay, Tamas

AU - Gemetchu, Teferi

AU - Humber, David

AU - Ersamo, Mulugetta

AU - Evans, David

AU - Teferedegn, Hailu

AU - Phelouzat, Marie Anne

AU - Frommel, Dominique

PY - 1992/1/1

Y1 - 1992/1/1

N2 - The borough of Ocholo, on the western side of the Ethiopian Rift Valley, is an endemic focus for Leishmania aethiopica infection and has been surveyed thrice between 1987 and 1990. In 1989, 3022 inhabitants (>95% of the population) were interviewed and examined. The overall prevalence of localized cutaneous leishmaniasis (LCL) was 3.6-4.0%, with a peak value of 8.5% in the 0-10 years old age group. In half of the patients the active disease was estimated to last for 9.6±6 months; in 10%, it exceeded 3 years. Scars of LCL were present in 34.3% of the residents. Leishmanin skin tests were positive in 54% of 120 school-children without signs of the disease. Therefore, in Ocholo a minimum of 71.6% of the population has been exposed to L. aethiopica infection. Two cases of the diffuse form of cutaneous leishmaniasis were observed. In this highland biotope, Phlebotomus pedifer was found to be the major, and possibly the only, vector for L. aethiopica.

AB - The borough of Ocholo, on the western side of the Ethiopian Rift Valley, is an endemic focus for Leishmania aethiopica infection and has been surveyed thrice between 1987 and 1990. In 1989, 3022 inhabitants (>95% of the population) were interviewed and examined. The overall prevalence of localized cutaneous leishmaniasis (LCL) was 3.6-4.0%, with a peak value of 8.5% in the 0-10 years old age group. In half of the patients the active disease was estimated to last for 9.6±6 months; in 10%, it exceeded 3 years. Scars of LCL were present in 34.3% of the residents. Leishmanin skin tests were positive in 54% of 120 school-children without signs of the disease. Therefore, in Ocholo a minimum of 71.6% of the population has been exposed to L. aethiopica infection. Two cases of the diffuse form of cutaneous leishmaniasis were observed. In this highland biotope, Phlebotomus pedifer was found to be the major, and possibly the only, vector for L. aethiopica.

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JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

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ER -

Cutaneous leishmaniasis in south-western Ethiopia: Ocholo revisited

Abstract

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