Current approaches for risk stratification of infectious complications in pediatric oncology

Christoph Härtel*, Maresa Deuster, Thomas Lehrnbecher, Christian Schultz

*Corresponding author for this work
33 Citations (Scopus)


Infections are serious complications of cytoreductive therapy in pediatric cancer patients presenting with febrile neutropenia. It is standard of care to initiate empirical intravenous broad-spectrum antibiotics until the fever and neutropenia resolve. However, it might be effective and safe to allow for early hospital discharge in certain subgroups of patients. Two strategies for risk stratification of pediatric cancer patients with regard to infectious complications are discussed in this review: (1) clinical risk parameters and laboratory measures to assist therapeutic management at presentation with fever in neutropenia, and (2) investigations of individual genetic susceptibility factors to tailor potential prophylactic approaches. Given the data available from a significant number of small studies, a large prospective non-inferiority trial is essential to assess low-risk clinical factors and additional laboratory or genetic markers for their predictive value.

Original languageEnglish
JournalPediatric Blood and Cancer
Issue number6
Pages (from-to)767-773
Number of pages7
Publication statusPublished - 11.2007

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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