CSA: Comprehensive comparison of pairwise protein structure alignments

Inken Wohlers*, Noël Malod-Dognin, Rumen Andonov, Gunnar W. Klau

*Corresponding author for this work
12 Citations (Scopus)


CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl.

Original languageEnglish
JournalNucleic Acids Research
Issue numberW1
Pages (from-to)W303-W309
Publication statusPublished - 07.2012


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