CSA: Comprehensive comparison of pairwise protein structure alignments

Inken Wohlers; Noël Malod-Dognin; Rumen Andonov; Gunnar W. Klau

doi:10.1093/nar/gks362

CSA: Comprehensive comparison of pairwise protein structure alignments

Inken Wohlers^*, Noël Malod-Dognin, Rumen Andonov, Gunnar W. Klau

^*Corresponding author for this work

Clinic of Neurology

12 Citations (Scopus)

Abstract

CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl.

Original language	English
Journal	Nucleic Acids Research
Volume	40
Issue number	W1
Pages (from-to)	W303-W309
ISSN	0305-1048
DOIs	https://doi.org/10.1093/nar/gks362
Publication status	Published - 07.2012

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10.1093/nar/gks362

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abstract = "CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl.",

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AU - Wohlers, Inken

AU - Malod-Dognin, Noël

AU - Andonov, Rumen

AU - Klau, Gunnar W.

N1 - Funding Information: Deutsche Forschungsgemeinschaft [KL 1390/2-1, in part]. Funding for open access charge: INRIA Sophia Antipolis – Méditerranée.

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AB - CSA is a web server for the computation, evaluation and comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance-based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl.

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CSA: Comprehensive comparison of pairwise protein structure alignments

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