Critical investigation of the CD14 promoter polymorphism: Lack of a role for in vitro cytokine response and membrane CD14 expression

Sonja Von Aulock; Jan Rupp; Katja Gueinzius; Matthias Maass; Corinna Hermann

doi:10.1128/CDLI.12.10.1254-1256.2005

Critical investigation of the CD14 promoter polymorphism: Lack of a role for in vitro cytokine response and membrane CD14 expression

Sonja Von Aulock, Jan Rupp, Katja Gueinzius, Matthias Maass, Corinna Hermann^*

^*Corresponding author for this work

7 Citations (Scopus)

Abstract

Blood of volunteers, genotyped for the CD14 C(-159)→T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.

Original language	English
Journal	Clinical and Diagnostic Laboratory Immunology
Volume	12
Issue number	10
Pages (from-to)	1254-1256
Number of pages	3
ISSN	1071-412X
DOIs	https://doi.org/10.1128/CDLI.12.10.1254-1256.2005
Publication status	Published - 01.10.2005

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1128/CDLI.12.10.1254-1256.2005

Cite this

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title = "Critical investigation of the CD14 promoter polymorphism: Lack of a role for in vitro cytokine response and membrane CD14 expression",

abstract = "Blood of volunteers, genotyped for the CD14 C(-159)→T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.",

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AU - Von Aulock, Sonja

AU - Rupp, Jan

AU - Gueinzius, Katja

AU - Maass, Matthias

AU - Hermann, Corinna

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Blood of volunteers, genotyped for the CD14 C(-159)→T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.

AB - Blood of volunteers, genotyped for the CD14 C(-159)→T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.

UR - https://www.scopus.com/pages/publications/26944479246

U2 - 10.1128/CDLI.12.10.1254-1256.2005

DO - 10.1128/CDLI.12.10.1254-1256.2005

M3 - Journal articles

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SP - 1254

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JF - Clinical and Diagnostic Laboratory Immunology

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Critical investigation of the CD14 promoter polymorphism: Lack of a role for in vitro cytokine response and membrane CD14 expression

Abstract

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