Corticosteriod-binding globulin is not decreased in depressed patients

M. Deuschle*, U. Schweiger, H. Standhardt, B. Weber, I. Heuser

*Corresponding author for this work
13 Citations (Scopus)


We studied corticosteroid-binding globulin (CBG) in 25 drug-free depressed patients and 33 healthy controls over a wide age-range. CBG was measured at 0800, 1400, 2000 and 2400 h in all subjects. Analysis of variance (ANOVA) with repeated measurement design revealed a significant effect of gender and time, but not of diagnosis (depressed patients vs healthy controls) or age group (< 50/> 50 years). In females, regardless of diagnosis, CBG plasma concentrations were significantly increased, when compared with their male counterparts. Although as a group depressed patients had significantly higher plasma cortisol concentrations (108.0 ± 23.1 vs 70.7 ± 10.9 μg/l), CBG levels did not differ between the two groups. Thus we did not find hypercortisolemia in depression to be paralleled by a decrease in CBG. However, the exaggerated activity of the hypothalamus-pituitary-adrenocortical system in healthy and depressed females is associated with an increase in plasma CBG.

Original languageEnglish
Issue number8
Pages (from-to)645-649
Number of pages5
Publication statusPublished - 11.1996


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