Correlation between the level of cholesteryl ester transfer protein in follicular fluid with fertilization rates in IVF/ ICSI cycles

Amir Mehdizadeh, Ali Rahimipour, Laya Farzadi, Masoud Darabi, Vahideh Shahnazi, Maghsod Shaaker, Amir Mansour Vatankhah, Zahra Golmohamadi, Mohammad Nouri*

*Corresponding author for this work
8 Citations (Scopus)

Abstract

Background: Follicular fluid (FF) plays an important role in oocytes and embryo development, which may contribute to IVF/ICSI success rate. Objective: The aim of this study was to investigate the correlation between cholesteryl ester transfer protein (CETP) level in FF and the success rate of IVF/ICSI. Materials and Methods: In a cross-sectional study, FF samples, FF samples were obtained from 100 patients referred to Tabriz Alzahra Hospital. Seventy-nine subjects underwent IVF and the remaining 21 underwent ICSI. The levels of high-density lipoprotein cholesterol (HDL-C), apolipoprotein A-I and CETP were measured using enzymatic, turbidometric and ELISA methods respectively. Results: Analysis of the subgroups with different levels of CETP showed a significant lower level of CETP in the subgroup with the lowest number of mature oocytes (p<0.05). The level of CETP was also considerably lower (18%, p=0.05) in subjects with<50% oocytes fertilization ratio than subjects with >70% of this ratio. Conclusion: While no association was found for pregnancy, the amount of CETP in FF was associated positively to the maturity and the percentage of oocyte fertilization.

Original languageEnglish
JournalIranian Journal of Reproductive Medicine
Volume9
Issue number3
Pages (from-to)193-198
Number of pages6
ISSN1680-6433
Publication statusPublished - 2011

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