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Abstract
Background: Breast cancer in young women is associated with unfavourable tumour biology and is the main cause of death in this group. Conditional survival analysis estimates survival rates under the pre-condition of already having survived a certain time. Objectives: To describe conditional disease-free and overall survival of female breast cancer patients according to clinical subtypes and age. Methods: This study analyses information from 1,858 breast cancer patients aged between 21 and 54 years, who were taking part in a post-therapeutic rehab programme (time between diagnosis and rehab start: maximum 24, median 11 months). Mean follow-up time was 3.6 years. We describe biological, clinical and pathological features in regard to different age groups (<40 and ≥40 years) and report conditional 5-year survival rates for overall and disease-free survival, and Cox proportional hazard models. Results: Very young and young patients differed in regard to hormone receptor negativity, tumour grade, lymphovascular invasion, and molecular subtypes. Young women bore triple-negative and HER2-like disease more frequently. Conditional 5-year overall survival did not differ substantially between women <40 and 40-54 years of age (95 vs. 96%). It was highest for women with cancer of the luminal A subtype (98%) and lowest for the triple-negative subtype (91%). Lymphangiosis was a significant predictor of death. Results for disease-free survival were comparable. Conclusions: Conditional 5-year overall survival after non-metastatic breast cancer was as high as 95.5%, and disease-free survival was 85.2%. When controlling for time between diagnosis and rehab start, molecular subtypes influenced overall and disease-free survival prospects. When additionally controlling for clinical characteristics, this effect only remained stable for disease-free survival.
Original language | English |
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Journal | Breast Care |
Volume | 16 |
Issue number | 2 |
Pages (from-to) | 163-172 |
ISSN | 1661-3791 |
DOIs | |
Publication status | Published - 2021 |
Research Areas and Centers
- Research Area: Center for Population Medicine and Public Health (ZBV)
DFG Research Classification Scheme
- 2.22-02 Public Health, Healthcare Research, Social and Occupational Medicine
- 2.22-14 Hematology, Oncology
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Dive into the research topics of 'Conditional Disease-Free and Overall Survival of 1,858 Young Women with Non-Metastatic Breast Cancer and with Participation in a Post-Therapeutic Rehab Programme according to Clinical Subtypes'. Together they form a unique fingerprint.Projects
- 1 Finished
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Grömitz - Charakteristika und Lebensqualität junger Frauen mit Mammakarzinom
Katalinic, A. (Principal Investigator (PI)), Fischer, D. (Principal Investigator (PI)), Waldmann, A. (Principal Investigator (PI)), Hammersen, F. (Project Staff), Pursche, T. (Project Staff), Strobel, A. M. (Project Staff) & Labohm, L. (Project Staff)
01.01.11 → 31.12.24
Project: Projects with Federal Funding › GBA Projects (Innovation Fund)