Concentrations of inflammatory cytokines and the outcome in ICSI cycles

Byron Asimakopoulos, Cem Demirel, Ricardo Felberbaum, Steven Waczek, Nikos Nikolettos*, Frank Köster, Safaa Al-Hasani, Klaus Diedrich

*Corresponding author for this work
8 Citations (Scopus)


The aim of this study was to measure circulating and intrafollicular concentrations of three inflammatory cytokines from women undergoing ovarian stimulation in order to determine their prognostic value in the outcome of intracytoplasmic sperm injection/embryo transfer cycles. Materials and Methods: A total of 72 women following ovarian stimulation and intracytoplasmic sperm injection were included. Blood serum samples were drawn at the day of chorionic gonadotropin administration. Follicular fluids were collected at the day of oocyte retrieval. The total fractions of tumor necrosis factor α, interleukin (IL)-1β and IL-6 were measured with commercially available immunoassays. Results: The concentrations of IL-1β, both in serum and follicular fluids, were significantly different between ICSI cycles that resulted in pregnancy and those that failed. The concentrations of the other two cytokines did not significantly differ between successful and unsuccessful cycles. Conclusion: The circulating and intrafollicular concentrations of IL-1β seem to be related to the pregnancy outcome in ICSI cycles of healthy women.

Original languageEnglish
JournalIn Vivo
Issue number4
Pages (from-to)495-500
Number of pages6
Publication statusPublished - 01.07.2010

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


Dive into the research topics of 'Concentrations of inflammatory cytokines and the outcome in ICSI cycles'. Together they form a unique fingerprint.

Cite this