Complex genetics of Wegener granulomatosis

Peter Jagiello; Wolfgang L. Gross; Jörg T. Epplen

doi:10.1016/j.autrev.2004.06.003

Complex genetics of Wegener granulomatosis

Peter Jagiello^*, Wolfgang L. Gross, Jörg T. Epplen

^*Corresponding author for this work

Clinic of Rheumatology

Ruhr-University Bochum

36 Citations (Scopus)

Abstract

Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen. WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches.

Original language	English
Journal	Autoimmunity Reviews
Volume	4
Issue number	1
Pages (from-to)	42-47
Number of pages	6
ISSN	1568-9972
DOIs	https://doi.org/10.1016/j.autrev.2004.06.003
Publication status	Published - 01.2005

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.autrev.2004.06.003

Cite this

@article{1100e375319140cd9aa41c68418921c5,

title = "Complex genetics of Wegener granulomatosis",

abstract = "Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen. WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches.",

author = "Peter Jagiello and Gross, \{Wolfgang L.\} and Epplen, \{J{\"o}rg T.\}",

year = "2005",

month = jan,

doi = "10.1016/j.autrev.2004.06.003",

language = "English",

volume = "4",

pages = "42--47",

journal = "Autoimmunity Reviews",

issn = "1568-9972",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Complex genetics of Wegener granulomatosis

AU - Jagiello, Peter

AU - Gross, Wolfgang L.

AU - Epplen, Jörg T.

PY - 2005/1

Y1 - 2005/1

N2 - Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen. WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches.

AB - Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen. WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches.

UR - https://www.scopus.com/pages/publications/12344298537

U2 - 10.1016/j.autrev.2004.06.003

DO - 10.1016/j.autrev.2004.06.003

M3 - Scientific review articles

C2 - 15652778

AN - SCOPUS:12344298537

SN - 1568-9972

VL - 4

SP - 42

EP - 47

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

IS - 1

ER -

Complex genetics of Wegener granulomatosis

Abstract

Research Areas and Centers

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this