Complex genetics of Wegener granulomatosis

Peter Jagiello*, Wolfgang L. Gross, Jörg T. Epplen

*Corresponding author for this work
36 Citations (Scopus)


Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen. WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches.

Original languageEnglish
JournalAutoimmunity Reviews
Issue number1
Pages (from-to)42-47
Number of pages6
Publication statusPublished - 01.2005

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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