Complex genetics of Wegener granulomatosis

Peter Jagiello; Wolfgang L. Gross; Jörg T. Epplen

doi:10.1016/j.autrev.2004.06.003

Complex genetics of Wegener granulomatosis

Peter Jagiello^*, Wolfgang L. Gross, Jörg T. Epplen

^*Corresponding author for this work

Clinic of Rheumatology

Ruhr-University Bochum

36 Citations (Scopus)

Abstract

Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen. WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches.

Original language	English
Journal	Autoimmunity Reviews
Volume	4
Issue number	1
Pages (from-to)	42-47
Number of pages	6
ISSN	1568-9972
DOIs	https://doi.org/10.1016/j.autrev.2004.06.003
Publication status	Published - 01.2005

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1016/j.autrev.2004.06.003

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abstract = "Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen. WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches.",

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AB - Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen. WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches.

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Complex genetics of Wegener granulomatosis

Abstract

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