Complement-tapping into new sites and effector systems

Martin Kolev, Gaelle Le Friec, Claudia Kemper*

*Corresponding author for this work
180 Citations (Scopus)


Complement is traditionally known to be a system of serum proteins that provide protection against pathogens through direct cell lysis and the mobilization of innate and adaptive immunity. However, recent work indicates that the complement system has additional physiological roles beyond those in host defence. In this Opinion article, we describe the new modes and locations of complement activation that enable it to interact with other cell effector systems, such as growth factor receptors, inflammasomes and metabolic pathways. We propose that the location of complement activation dictates its function.

Original languageEnglish
JournalNature Reviews Immunology
Issue number12
Pages (from-to)811-820
Number of pages10
Publication statusPublished - 11.12.2014

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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