Complement nomenclature-deconvoluted

Suzanne S. Bohlson; Peter Garred; Claudia Kemper; Andrea J. Tenner

doi:10.3389/fimmu.2019.01308

Complement nomenclature-deconvoluted

Suzanne S. Bohlson, Peter Garred, Claudia Kemper, Andrea J. Tenner^*

^*Corresponding author for this work

Institute of Systemic Inflammation Research

85 Citations (Scopus)

Abstract

In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended.

Original language	English
Article number	1308
Journal	Frontiers in Immunology
Volume	10
Issue number	JUN
Pages (from-to)	1308
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2019.01308
Publication status	Published - 01.01.2019

Funding

1Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, United States, 2Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet University Hospital of Copenhagen, Copenhagen, Denmark, 3Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States, 4Department of Molecular Biology and Biochemistry, Department of Neurobiology and Behavior, Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, United States This contribution was supported by funds from NIH National Institute of Allergy and Infectious Diseases R15AI117474-01A1 (SB), the Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH (CK) as well as Danish Research Foundation of Independent Research [DFF-6110-00489], the Novo Nordisk Research Foundation and the Sven Andersen Research Foundation (PG) and NIH National Institute on Aging R01 AG060148 (AT).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.3389/fimmu.2019.01308

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AB - In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended.

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Complement nomenclature-deconvoluted

Abstract

Funding

UN SDGs

Research Areas and Centers

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