Complement nomenclature-deconvoluted

Suzanne S. Bohlson; Peter Garred; Claudia Kemper; Andrea J. Tenner

doi:10.3389/fimmu.2019.01308

Complement nomenclature-deconvoluted

Suzanne S. Bohlson, Peter Garred, Claudia Kemper, Andrea J. Tenner^*

^*Corresponding author for this work

Institute of Systemic Inflamation Research

Abstract

In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended.

Original language	English
Article number	1308
Journal	Frontiers in Immunology
Volume	10
Issue number	JUN
Pages (from-to)	1308
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2019.01308
Publication status	Published - 01.01.2019

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fimmu.2019.01308

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title = "Complement nomenclature-deconvoluted",

abstract = "In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended.",

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AU - Bohlson, Suzanne S.

AU - Garred, Peter

AU - Kemper, Claudia

AU - Tenner, Andrea J.

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Y1 - 2019/1/1

N2 - In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended.

AB - In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended.

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DO - 10.3389/fimmu.2019.01308

M3 - Scientific review articles

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JO - Frontiers in Immunology

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M1 - 1308

ER -

Complement nomenclature-deconvoluted

Abstract

Research Areas and Centers

UN SDGs

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