Abstract
Complement is well appreciated as a critical arm of innate immunity. It is required for the removal of invading pathogens and works by directly destroying them through the activation of innate and adaptive immune cells. However, complement activation and function is not confined to the extracellular space but also occurs within cells. Recent work indicates that complement activation regulates key metabolic pathways and thus can impact fundamental cellular processes, such as survival, proliferation, and autophagy. Newly identified functions of complement include a key role in shaping metabolic reprogramming, which underlies T cell effector differentiation, and a role as a nexus for interactions with other effector systems, in particular the inflammasome and Notch transcription-factor networks. This review focuses on the contributions of complement to basic processes of the cell, in particular the integration of complement with cellular metabolism and the potential implications in infection and other disease settings.
| Original language | English |
|---|---|
| Journal | Immunity |
| Volume | 45 |
| Issue number | 2 |
| Pages (from-to) | 240-254 |
| Number of pages | 15 |
| ISSN | 1074-7613 |
| DOIs | |
| Publication status | Published - 2016 |
Funding
Work in the Hess and Kemper laboratories is supported by MRC Centre grant MR/J006742/1, an EU-funded Innovative Medicines Initiative BTCURE (C.K.), a Wellcome Trust Investigator Award (C.K.), the King’s Bioscience Institute at King’s College London (G.A.), the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, the Division of Intramural Research of the National Heart, Lung, and Blood Institute at the NIH, the intramural research program of NIAID, NIH, the Swiss National Science Foundation (310030_154059 and CRSII_160766) (C.H.), the Gebert-Rüf Foundation (GER-058/14), and the Swiss Cancer League (KFS-3773-08-2015).
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
