TY - JOUR
T1 - Complement in trauma—Traumatised complement?
AU - Huber-Lang, Markus S.
AU - Ignatius, Anita
AU - Köhl, Jörg
AU - Mannes, Marco
AU - Braun, Christian Karl
N1 - Funding Information:
This review was supported by the CRC 1149 A01 (INST 40/479‐2) and B02 (INST 40/487‐2).
Publisher Copyright:
© 2020 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9/3
Y1 - 2020/9/3
N2 - Physical trauma represents a major global burden. The trauma-induced response, including activation of the innate immune system, strives for regeneration but can also lead to post-traumatic complications. The complement cascade is rapidly activated by damaged tissue, hypoxia, exogenous proteases and others. Activated complement can sense, mark and clear both damaged tissue and pathogens. However, excessive and insufficient activation of complement can result in a dysfunctional immune and organ response. Similar to acute coagulopathy, complementopathy can develop with enhanced anaphylatoxin generation and an impairment of complement effector functions. Various remote organ effects are induced or modulated by complement activation. Frequently, established trauma treatments are double-edged. On one hand, they help stabilising haemodynamics and oxygen supply as well as injured organs and on the other hand, they also drive complement activation. Immunomodulatory approaches aim to reset trauma-induced disbalance of complement activation and thus may change surgical trauma management procedures to improve outcome.
AB - Physical trauma represents a major global burden. The trauma-induced response, including activation of the innate immune system, strives for regeneration but can also lead to post-traumatic complications. The complement cascade is rapidly activated by damaged tissue, hypoxia, exogenous proteases and others. Activated complement can sense, mark and clear both damaged tissue and pathogens. However, excessive and insufficient activation of complement can result in a dysfunctional immune and organ response. Similar to acute coagulopathy, complementopathy can develop with enhanced anaphylatoxin generation and an impairment of complement effector functions. Various remote organ effects are induced or modulated by complement activation. Frequently, established trauma treatments are double-edged. On one hand, they help stabilising haemodynamics and oxygen supply as well as injured organs and on the other hand, they also drive complement activation. Immunomodulatory approaches aim to reset trauma-induced disbalance of complement activation and thus may change surgical trauma management procedures to improve outcome.
UR - http://www.scopus.com/inward/record.url?scp=85094583321&partnerID=8YFLogxK
U2 - 10.1111/bph.15245
DO - 10.1111/bph.15245
M3 - Scientific review articles
C2 - 32880897
AN - SCOPUS:85094583321
SN - 0007-1188
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
ER -