Complement in motion: The evolution of CD46 from a complement regulator to an orchestrator of normal cell physiology

M. Kathryn Liszewski; Claudia Kemper

doi:10.4049/jimmunol.1900527

Complement in motion: The evolution of CD46 from a complement regulator to an orchestrator of normal cell physiology

M. Kathryn Liszewski^*, Claudia Kemper

^*Corresponding author for this work

Institute of Systemic Inflammation Research

Washington University in St. Louis

31 Citations (Scopus)

Abstract

The classic pathogen-fighting functions of our microbe sensing systems, such as the TLRs, the Nod-like receptors, and several proteins of the complement system, had been defined relatively rapidly after their discovery (1, 2). A more recent trend, however, clearly indicates that some of these evolutionarily ancient systems also serve additional, noncanonical roles in normal cell physiology. In this article, we highlight how the functions of the complement component CD46 have expanded dramatically beyond its initial discovery as a regulator of complement activation. We now recognize this ancient molecule as a biological focal point for our continuously evolving understanding of the diverse roles of complement as a key orchestrator of (immunological) health.

...

Original language	English
Journal	Journal of Immunology
Volume	203
Issue number	1
Pages (from-to)	3-5
Number of pages	3
ISSN	0022-1767
DOIs	https://doi.org/10.4049/jimmunol.1900527
Publication status	Published - 01.07.2019

Funding

*Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110; †Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; ‡School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King’s College London, London SE1 9RT, United Kingdom; and xInstitute for Systemic Inflammation Research, University of Lubeck, 23562 Lubeck, Germany Work in the Kemper laboratory is supported by the Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health. M.K.L. support was provided by the National Institutes of Health (Grant R01 GM099111).

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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Complement in motion: The evolution of CD46 from a complement regulator to an orchestrator of normal cell physiology

Abstract

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