Complement component C5 recruits neutrophils in the absence of C3 during respiratory infection with modified vaccinia virus Ankara

Philip J.R. Price, Zoltán Bánki, Angelika Scheideler, Heribert Stoiber, Admar Verschoor, Gerd Sutter, Michael H. Lehmann*

*Corresponding author for this work
    12 Citations (Scopus)

    Abstract

    Efficient leukocyte migration is important for an effective host response to viral infection and the development ofadaptive immunity. The poxvirus strain modified vaccinia virus Ankara (MVA), a safe and efficient viral vector, rapidly induces chemokine expression and respiratory recruitment of leukocytes, which is unique among vaccinia viruses. In addition to chemokines, the complement system contributes to the attraction and activation of different types of leukocytes. Using a murine model of intranasal infection, we show in this study that MVA-induced neutrophil recruitment depends on complement component C5. Remarkably, we find that C5 mediates neutrophil recruitment to the lung, even in the absence of the central complement component C3. Our findings argue for complement C5 activation during MVA infection of the lung via a C3-independent pathway, which enables rapid recruitment of neutrophils.

    Original languageEnglish
    JournalJournal of Immunology
    Volume194
    Issue number3
    Pages (from-to)1164-1168
    Number of pages5
    ISSN0022-1767
    DOIs
    Publication statusPublished - 01.02.2015

    Research Areas and Centers

    • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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