Abstract
The complement system represents one of the evolutionary oldest arms of our immune system and is commonly recognized as a liver-derived and serum-active system critical for providing protection against invading pathogens. Recent unexpected findings, however, have defined novel and rather “uncommon” locations and activities of complement. Specifically, the discovery of an intracellularly active complement system—the complosome—and its key role in the regulation of cell metabolic pathways that underly normal human T cell responses have taught us that there is still much to be discovered about this system. Here, we summarize the current knowledge about the emerging functions of the complosome in T cell metabolism. We further place complosome activities among the non-canonical roles of other intracellular innate danger sensing systems and argue that a “location-centric” view of complement evolution could logically justify its close connection with the regulation of basic cell physiology.
| Original language | English |
|---|---|
| Journal | Immunological Reviews |
| Volume | 295 |
| Issue number | 1 |
| Pages (from-to) | 68-81 |
| Number of pages | 14 |
| ISSN | 0105-2896 |
| DOIs | |
| Publication status | Published - 01.05.2020 |
Funding
Work in the Complement and Inflammation Research Section (CIRS,?Kemper laboratory) was/is financed by the MRC Centre grant MR/J006742/1, an EU-funded Innovative Medicines Initiative BTCURE, a Wellcome Trust Investigator Award, the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London, and by the Division of Intramural Research, National Heart, Lung, and Blood Institute (NHLBI), NIH. We further acknowledge the work of the many scientists, particularly working on T cell metabolism, that we were unable to cite here due to focus on the complosome and T cell metabolism.
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
