Comparison between conventional hemodynamic monitoring and polarographic tissue pO2-monitoring of the liver in early septicemia of the pig

K. Wagner; R. Schäfer; W. Gerling; A. Michelsen; P. Schmucker

doi:10.1007/978-1-4613-0333-6_10

Comparison between conventional hemodynamic monitoring and polarographic tissue pO₂-monitoring of the liver in early septicemia of the pig

K. Wagner^*, R. Schäfer, W. Gerling, A. Michelsen, P. Schmucker

^*Corresponding author for this work

2 Citations (Scopus)

Abstract

The common therapeutic approach to septicemia - aside from elimination of its cause and antibiosis - consists of the attempt to keep tissue perfusion within physiological limits. A frequently employed therapeutic option is catecholamine administration. Since the reduction of peripheral vascular resistance in septicemia is at least partly due to a TNF induced vascular NO-synthase, the inhibition of this system does affect tissue perfusion as well. While there are controversial results as to the benefit of inhibition of NO-synthase on mean arterial pressure (MAP) and cardiac index (CI) (1) the effect of NO-synthase inhibition on liver circulation has not been described. In addition we were interested in the effect of NO-synthase inhibition on liver pO2.
´

Original language	English
Journal	Advances in experimental medicine and biology
Volume	388
Pages (from-to)	85-92
Number of pages	8
ISSN	0065-2598
DOIs	https://doi.org/10.1007/978-1-4613-0333-6_10
Publication status	Published - 1996

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-4613-0333-6_10

Cite this

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title = "Comparison between conventional hemodynamic monitoring and polarographic tissue pO2-monitoring of the liver in early septicemia of the pig",

abstract = "The common therapeutic approach to septicemia - aside from elimination of its cause and antibiosis - consists of the attempt to keep tissue perfusion within physiological limits. A frequently employed therapeutic option is catecholamine administration. Since the reduction of peripheral vascular resistance in septicemia is at least partly due to a TNF induced vascular NO-synthase, the inhibition of this system does affect tissue perfusion as well. While there are controversial results as to the benefit of inhibition of NO-synthase on mean arterial pressure (MAP) and cardiac index (CI) (1) the effect of NO-synthase inhibition on liver circulation has not been described. In addition we were interested in the effect of NO-synthase inhibition on liver pO2.´",

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T1 - Comparison between conventional hemodynamic monitoring and polarographic tissue pO2-monitoring of the liver in early septicemia of the pig

AU - Wagner, K.

AU - Schäfer, R.

AU - Gerling, W.

AU - Michelsen, A.

AU - Schmucker, P.

PY - 1996

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N2 - The common therapeutic approach to septicemia - aside from elimination of its cause and antibiosis - consists of the attempt to keep tissue perfusion within physiological limits. A frequently employed therapeutic option is catecholamine administration. Since the reduction of peripheral vascular resistance in septicemia is at least partly due to a TNF induced vascular NO-synthase, the inhibition of this system does affect tissue perfusion as well. While there are controversial results as to the benefit of inhibition of NO-synthase on mean arterial pressure (MAP) and cardiac index (CI) (1) the effect of NO-synthase inhibition on liver circulation has not been described. In addition we were interested in the effect of NO-synthase inhibition on liver pO2.´

AB - The common therapeutic approach to septicemia - aside from elimination of its cause and antibiosis - consists of the attempt to keep tissue perfusion within physiological limits. A frequently employed therapeutic option is catecholamine administration. Since the reduction of peripheral vascular resistance in septicemia is at least partly due to a TNF induced vascular NO-synthase, the inhibition of this system does affect tissue perfusion as well. While there are controversial results as to the benefit of inhibition of NO-synthase on mean arterial pressure (MAP) and cardiac index (CI) (1) the effect of NO-synthase inhibition on liver circulation has not been described. In addition we were interested in the effect of NO-synthase inhibition on liver pO2.´

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