Abstract
Gray-zone lymphoma (GZL) reflects an aggressive B-cell neoplasm with features intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL). The International Prognostic Index (IPI) and its derivatives (R-IPI, NCCN-IPI, and the Hasenclever IPS) have been established for DLBCL or cHL while the most suitable scoring system for GZL remains undetermined. In an exploratory multi-centric cohort of GZL (n = 61), we performed a comparative analysis of prognostic indices with regard to model fit and mutual concordance. The calculation of the corrected Akaike’s information criterion (cAIC) and Harrel’s concordance index (c-index) for each scoring system identified the NCCN-IPI to harbor the most convincing prognostic capabilities regarding both overall survival (OS) and progression-free survival (PFS) compared to its enhanced derivatives. The current results affirm the clinical utility of the NCCN-IPI and suggest its preferential use in clinical practice in GZL-patients.
| Original language | English |
|---|---|
| Journal | Leukemia and Lymphoma |
| Volume | 63 |
| Issue number | 4 |
| Pages (from-to) | 894-902 |
| Number of pages | 9 |
| ISSN | 1042-8194 |
| DOIs | |
| Publication status | Published - 2022 |
Research Areas and Centers
- Research Area: Luebeck Integrated Oncology Network (LION)
- Centers: University Cancer Center Schleswig-Holstein (UCCSH)
- Research Area: Medical Genetics
DFG Research Classification Scheme
- 2.22-14 Hematology, Oncology
