Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets

Dragos Inta; Bettina K. Wölnerhanssen; Anne Christin Meyer-Gerspach; Elisabeth Lang; Nina Schweinfurth; Anne S. Mallien; Andrei Nicolae Vasilescu; André Schmidt; Kieran Rea; Astrid M. Westendorf; Marie Ève Tremblay; Alexander Sartorius; Peter Gass; John F. Cryan; Stefan Borgwardt; Undine E. Lang

doi:10.1007/s40473-020-00199-1

Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets

Dragos Inta^*, Bettina K. Wölnerhanssen, Anne Christin Meyer-Gerspach, Elisabeth Lang, Nina Schweinfurth, Anne S. Mallien, Andrei Nicolae Vasilescu, André Schmidt, Kieran Rea, Astrid M. Westendorf, Marie Ève Tremblay, Alexander Sartorius, Peter Gass, John F. Cryan, Stefan Borgwardt, Undine E. Lang

^*Corresponding author for this work

Clinic of Psychiatry and Psychotherapy

5 Citations (Scopus)

Abstract

Purpose of Review: This paper aims to review data regarding two determinants of comorbidity between depression and obesity, i.e., the role of disturbed gut microbiome in their genesis and of diets in their treatment. Recent Findings: Obesity and major depressive disorders (MDD) are highly comorbid, the “metabolic” (obese) subtype of MDD affects about one third of all individuals with MDD. There is an urgent need for better therapies strategies, which may include specific dietary measures. A diet low in carbohydrates (low-carb), effective in obesity, may be beneficial also in MDD. However, the underlying mechanisms have not yet been elucidated. Recent data suggest a key role of gut microbiota, neuroplasticity, and neuroinflammation in obesity and MDD. We will focus on the brain-derived neurotrophic factor (BDNF), and microglial fractalkine, a main modulator of neuroinflammation. Summary: BDNF and fractalkine may be involved in “metabolic” depression. Future studies may uncover specific pathophysiological pathways in affected patients towards more efficient causal therapies.

Original language	English
Journal	Current Behavioral Neuroscience Reports
Volume	7
Issue number	1
Pages (from-to)	15-21
Number of pages	7
DOIs	https://doi.org/10.1007/s40473-020-00199-1
Publication status	Published - 01.03.2020

Funding

This work was supported by grants from the Deutsche Forschungsgemeinschaft (DFG, IN 168/3-1), the Ingeborg Ständer Foundation, the ERA-NET NEURON program, and the Bundesministerium für Bildung und Forschung (BMBF, 01EW1807A) to D.I., and the Canada Research Chair Tier II of Neuroimmune Plasticity in Health and Therapy to M.E.T.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

Access to Document

10.1007/s40473-020-00199-1

Cite this

Inta, D., Wölnerhanssen, B. K., Meyer-Gerspach, A. C., Lang, E., Schweinfurth, N., Mallien, A. S., Vasilescu, A. N., Schmidt, A., Rea, K., Westendorf, A. M., Tremblay, M. È., Sartorius, A., Gass, P., Cryan, J. F., Borgwardt, S., & Lang, U. E. (2020). Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets. Current Behavioral Neuroscience Reports, 7(1), 15-21. https://doi.org/10.1007/s40473-020-00199-1

@article{af4ab30ea9324910b2e0ed80c249272a,

title = "Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets",

abstract = "Purpose of Review: This paper aims to review data regarding two determinants of comorbidity between depression and obesity, i.e., the role of disturbed gut microbiome in their genesis and of diets in their treatment. Recent Findings: Obesity and major depressive disorders (MDD) are highly comorbid, the “metabolic” (obese) subtype of MDD affects about one third of all individuals with MDD. There is an urgent need for better therapies strategies, which may include specific dietary measures. A diet low in carbohydrates (low-carb), effective in obesity, may be beneficial also in MDD. However, the underlying mechanisms have not yet been elucidated. Recent data suggest a key role of gut microbiota, neuroplasticity, and neuroinflammation in obesity and MDD. We will focus on the brain-derived neurotrophic factor (BDNF), and microglial fractalkine, a main modulator of neuroinflammation. Summary: BDNF and fractalkine may be involved in “metabolic” depression. Future studies may uncover specific pathophysiological pathways in affected patients towards more efficient causal therapies.",

author = "Dragos Inta and W{\"o}lnerhanssen, \{Bettina K.\} and Meyer-Gerspach, \{Anne Christin\} and Elisabeth Lang and Nina Schweinfurth and Mallien, \{Anne S.\} and Vasilescu, \{Andrei Nicolae\} and Andr{\'e} Schmidt and Kieran Rea and Westendorf, \{Astrid M.\} and Tremblay, \{Marie {\`E}ve\} and Alexander Sartorius and Peter Gass and Cryan, \{John F.\} and Stefan Borgwardt and Lang, \{Undine E.\}",

note = "Publisher Copyright: {\textcopyright} 2020, Springer Nature Switzerland AG.",

year = "2020",

month = mar,

day = "1",

doi = "10.1007/s40473-020-00199-1",

language = "English",

volume = "7",

pages = "15--21",

journal = "Current Behavioral Neuroscience Reports",

issn = "2196-2979",

publisher = "Springer International Publishing AG",

number = "1",

}

Inta, D, Wölnerhanssen, BK, Meyer-Gerspach, AC, Lang, E, Schweinfurth, N, Mallien, AS, Vasilescu, AN, Schmidt, A, Rea, K, Westendorf, AM, Tremblay, MÈ, Sartorius, A, Gass, P, Cryan, JF, Borgwardt, S & Lang, UE 2020, 'Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets', Current Behavioral Neuroscience Reports, vol. 7, no. 1, pp. 15-21. https://doi.org/10.1007/s40473-020-00199-1

TY - JOUR

T1 - Common Pathways in Depression and Obesity

T2 - The Role of Gut Microbiome and Diets

AU - Inta, Dragos

AU - Wölnerhanssen, Bettina K.

AU - Meyer-Gerspach, Anne Christin

AU - Lang, Elisabeth

AU - Schweinfurth, Nina

AU - Mallien, Anne S.

AU - Vasilescu, Andrei Nicolae

AU - Schmidt, André

AU - Rea, Kieran

AU - Westendorf, Astrid M.

AU - Tremblay, Marie Ève

AU - Sartorius, Alexander

AU - Gass, Peter

AU - Cryan, John F.

AU - Borgwardt, Stefan

AU - Lang, Undine E.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Purpose of Review: This paper aims to review data regarding two determinants of comorbidity between depression and obesity, i.e., the role of disturbed gut microbiome in their genesis and of diets in their treatment. Recent Findings: Obesity and major depressive disorders (MDD) are highly comorbid, the “metabolic” (obese) subtype of MDD affects about one third of all individuals with MDD. There is an urgent need for better therapies strategies, which may include specific dietary measures. A diet low in carbohydrates (low-carb), effective in obesity, may be beneficial also in MDD. However, the underlying mechanisms have not yet been elucidated. Recent data suggest a key role of gut microbiota, neuroplasticity, and neuroinflammation in obesity and MDD. We will focus on the brain-derived neurotrophic factor (BDNF), and microglial fractalkine, a main modulator of neuroinflammation. Summary: BDNF and fractalkine may be involved in “metabolic” depression. Future studies may uncover specific pathophysiological pathways in affected patients towards more efficient causal therapies.

AB - Purpose of Review: This paper aims to review data regarding two determinants of comorbidity between depression and obesity, i.e., the role of disturbed gut microbiome in their genesis and of diets in their treatment. Recent Findings: Obesity and major depressive disorders (MDD) are highly comorbid, the “metabolic” (obese) subtype of MDD affects about one third of all individuals with MDD. There is an urgent need for better therapies strategies, which may include specific dietary measures. A diet low in carbohydrates (low-carb), effective in obesity, may be beneficial also in MDD. However, the underlying mechanisms have not yet been elucidated. Recent data suggest a key role of gut microbiota, neuroplasticity, and neuroinflammation in obesity and MDD. We will focus on the brain-derived neurotrophic factor (BDNF), and microglial fractalkine, a main modulator of neuroinflammation. Summary: BDNF and fractalkine may be involved in “metabolic” depression. Future studies may uncover specific pathophysiological pathways in affected patients towards more efficient causal therapies.

UR - https://www.scopus.com/pages/publications/85090083347

U2 - 10.1007/s40473-020-00199-1

DO - 10.1007/s40473-020-00199-1

M3 - Scientific review articles

AN - SCOPUS:85090083347

SN - 2196-2979

VL - 7

SP - 15

EP - 21

JO - Current Behavioral Neuroscience Reports

JF - Current Behavioral Neuroscience Reports

IS - 1

ER -

Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets

Abstract

Funding

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this