TY - JOUR
T1 - Common brain disorders are associated with heritable patterns of apparent aging of the brain
AU - Karolinska Schizophrenia Project (KaSP)
AU - Kaufmann, Tobias
AU - van der Meer, Dennis
AU - Doan, Nhat Trung
AU - Schwarz, Emanuel
AU - Lund, Martina J.
AU - Agartz, Ingrid
AU - Alnæs, Dag
AU - Barch, Deanna M.
AU - Baur-Streubel, Ramona
AU - Bertolino, Alessandro
AU - Bettella, Francesco
AU - Beyer, Mona K.
AU - Bøen, Erlend
AU - Borgwardt, Stefan
AU - Brandt, Christine L.
AU - Buitelaar, Jan
AU - Celius, Elisabeth G.
AU - Cervenka, Simon
AU - Conzelmann, Annette
AU - Córdova-Palomera, Aldo
AU - Dale, Anders M.
AU - de Quervain, Dominique J.F.
AU - Carlo, Pasquale Di
AU - Djurovic, Srdjan
AU - Dørum, Erlend S.
AU - Eisenacher, Sarah
AU - Elvsåshagen, Torbjørn
AU - Espeseth, Thomas
AU - Fatouros-Bergman, Helena
AU - Flyckt, Lena
AU - Franke, Barbara
AU - Frei, Oleksandr
AU - Haatveit, Beathe
AU - Håberg, Asta K.
AU - Harbo, Hanne F.
AU - Hartman, Catharina A.
AU - Heslenfeld, Dirk
AU - Hoekstra, Pieter J.
AU - Høgestøl, Einar A.
AU - Jernigan, Terry L.
AU - Jonassen, Rune
AU - Jönsson, Erik G.
AU - Farde, Lars
AU - Flyckt, Lena
AU - Engberg, Göran
AU - Erhardt, Sophie
AU - Fatouros-Bergman, Helena
AU - Cervenka, Simon
AU - Schwieler, Lilly
AU - Piehl, Fredrik
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3–96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
AB - Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3–96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
UR - https://www.scopus.com/pages/publications/85072625058
U2 - 10.1038/s41593-019-0471-7
DO - 10.1038/s41593-019-0471-7
M3 - Journal articles
C2 - 31551603
AN - SCOPUS:85072625058
SN - 1097-6256
VL - 22
SP - 1617
EP - 1623
JO - Nature Neuroscience
JF - Nature Neuroscience
IS - 10
ER -
SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities