TY - JOUR
T1 - Cohort profile
T2 - Follow-up of a Berlin Aging Study II (BASE-II) subsample as part of the GendAge study
AU - Demuth, Ilja
AU - Banszerus, Verena
AU - Drewelies, Johanna
AU - Düzel, Sandra
AU - Seeland, Ute
AU - Spira, Dominik
AU - Tse, Esther
AU - Braun, Julian
AU - Steinhagen-Thiessen, Elisabeth
AU - Bertram, Lars
AU - Thiel, Andreas
AU - Lindenberger, Ulman
AU - Regitz-Zagrosek, Vera
AU - Gerstorf, Denis
N1 - Funding Information:
Funding The GendAge study research project (Co-PIs are Ilja Demuth, Vera Regitz-Zagrosek, and Denis Gerstorf) is supported by the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF) grant numbers 01GL1716A (ID and VRZ) and 01GL1716B (DG). Genomics assessments are funded by the Cure Alzheimer’s Fund (as part of the “CIRCUITS-AD” consortium project) and the European Research Council’s “Horizon2020” funding scheme (as part of the “Lifebrain” consortium project; both to LB). Additional contributions (e.g., equipment, logistics, personnel) are made from each of the participating sites.
Publisher Copyright:
© 2021 BMJ Publishing Group. All rights reserved.
PY - 2021/6/23
Y1 - 2021/6/23
N2 - Purpose The study â € Sex- and gender-sensitive prevention of cardiovascular and metabolic disease in older adults in Germany', the GendAge study, focuses on major risk factors for cardiovascular and metabolic diseases and on the development of major outcomes from intermediate phenotypes in the context of sex and gender differences. It is based on a follow-up examination of a subsample (older group) of the Berlin Aging Study II (BASE-II). Participants The GendAge study assessments took place between 22 June 2018 and 10 March 2020. A total of 1100 participants (older BASE-II subsample, aged ≥65 years) with baseline data assessed at least by one of the BASE-II partner sites were investigated in the follow-up. These participants had a mean age of 75.6 years (SD ±3.8), with a mean follow-up at 7.4 years (SD ±1.5). Findings to date Data from different domains such as internal medicine, geriatrics, immunology and psychology were collected, with a focus on cardiometabolic diseases and in the context of sex and gender differences. Diabetes mellitus type 2 was reported by 15.6% and 8.6% of men and women, respectively. In contrast, this disease was diagnosed in 20.7% of men and 13.3% of women, indicating that a substantial proportion of almost 30% was unaware of the disease. Echocardiography revealed that left ventricular ejection fraction was higher in women than in men, in agreement with previous reports. Future plans A gender questionnaire assessing sociocultural aspects implemented as part of the follow-up described here will allow to calculate a gender score and its evaluation based on the newly collected data. At the same time, the other BASE-II research foci established over the past 10 years will be continued and strengthened by the BASE-II transition into a longitudinal study with follow-up data on the older subsample. Trial registration number DRKS00016157.
AB - Purpose The study â € Sex- and gender-sensitive prevention of cardiovascular and metabolic disease in older adults in Germany', the GendAge study, focuses on major risk factors for cardiovascular and metabolic diseases and on the development of major outcomes from intermediate phenotypes in the context of sex and gender differences. It is based on a follow-up examination of a subsample (older group) of the Berlin Aging Study II (BASE-II). Participants The GendAge study assessments took place between 22 June 2018 and 10 March 2020. A total of 1100 participants (older BASE-II subsample, aged ≥65 years) with baseline data assessed at least by one of the BASE-II partner sites were investigated in the follow-up. These participants had a mean age of 75.6 years (SD ±3.8), with a mean follow-up at 7.4 years (SD ±1.5). Findings to date Data from different domains such as internal medicine, geriatrics, immunology and psychology were collected, with a focus on cardiometabolic diseases and in the context of sex and gender differences. Diabetes mellitus type 2 was reported by 15.6% and 8.6% of men and women, respectively. In contrast, this disease was diagnosed in 20.7% of men and 13.3% of women, indicating that a substantial proportion of almost 30% was unaware of the disease. Echocardiography revealed that left ventricular ejection fraction was higher in women than in men, in agreement with previous reports. Future plans A gender questionnaire assessing sociocultural aspects implemented as part of the follow-up described here will allow to calculate a gender score and its evaluation based on the newly collected data. At the same time, the other BASE-II research foci established over the past 10 years will be continued and strengthened by the BASE-II transition into a longitudinal study with follow-up data on the older subsample. Trial registration number DRKS00016157.
UR - http://www.scopus.com/inward/record.url?scp=85108611532&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2020-045576
DO - 10.1136/bmjopen-2020-045576
M3 - Journal articles
C2 - 34162642
AN - SCOPUS:85108611532
SN - 2044-6055
VL - 11
JO - BMJ Open
JF - BMJ Open
IS - 6
M1 - e045576
ER -
