TY - JOUR
T1 - Cognitive deficits in spinocerebellar ataxia type 1, 2, and 3
AU - Bürk, K.
AU - Globas, C.
AU - Bösch, S.
AU - Klockgether, T.
AU - Zühlke, C.
AU - Daum, I.
AU - Dichgans, J.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Cognitive impairment was studied in distinct types of spinocerebellar ataxia (SCA): eleven SCA1, 14 SCA2, and 11 SCA3 individuals and 8 age- and IQ-matched controls. All were submitted to a neuropsychological test battery that comprised tests for IQ, attention, executive function, verbal and visuospatial memory. Executive dysfunction was prominent in SCA1 as compared with controls and all other SCA types. Mild deficits of verbal memory were present in SCA1, SCA2 and SCA3. The neuropathological pattern in different SCA types suggests that these cognitive deficits are not likely to be contingent upon cerebellar degeneration but to result from disruption of a cerebrocerebellar circuitry presumably at the pontine level.
AB - Cognitive impairment was studied in distinct types of spinocerebellar ataxia (SCA): eleven SCA1, 14 SCA2, and 11 SCA3 individuals and 8 age- and IQ-matched controls. All were submitted to a neuropsychological test battery that comprised tests for IQ, attention, executive function, verbal and visuospatial memory. Executive dysfunction was prominent in SCA1 as compared with controls and all other SCA types. Mild deficits of verbal memory were present in SCA1, SCA2 and SCA3. The neuropathological pattern in different SCA types suggests that these cognitive deficits are not likely to be contingent upon cerebellar degeneration but to result from disruption of a cerebrocerebellar circuitry presumably at the pontine level.
UR - http://www.scopus.com/inward/record.url?scp=0037320236&partnerID=8YFLogxK
U2 - 10.1007/s00415-003-0976-5
DO - 10.1007/s00415-003-0976-5
M3 - Journal articles
C2 - 12574952
AN - SCOPUS:0037320236
SN - 0340-5354
VL - 250
SP - 207
EP - 211
JO - Journal of Neurology
JF - Journal of Neurology
IS - 2
ER -
