Co-occurrence of autoantibodies in healthy blood donors

Jasper Prüßmann; Wiebke Prüßmann; Andreas Recke; Kristin Rentzsch; David Juhl; Reinhard Henschler; Susen Müller; Peter Lamprecht; Enno Schmidt; Elena Csernok; Siegfried Görg; Winfried Stöcker; Detlef Zillikens; Saleh M. Ibrahim; Ralf J. Ludwig

doi:10.1111/exd.12445

Co-occurrence of autoantibodies in healthy blood donors

Jasper Prüßmann, Wiebke Prüßmann, Andreas Recke, Kristin Rentzsch, David Juhl, Reinhard Henschler, Susen Müller, Peter Lamprecht, Enno Schmidt, Elena Csernok, Siegfried Görg, Winfried Stöcker, Detlef Zillikens, Saleh M. Ibrahim, Ralf J. Ludwig

Abstract

Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6,000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA positive compared to ANA negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens. This article is protected by copyright. All rights reserved.

Original language	English
Title of host publication	Experimental Dermatology
Number of pages	3
Publisher	Blackwell Publishing Ltd
Publication date	2014
Pages	519-521
ISBN (Print)	1600-0625 (Electronic)\r0906-6705 (Linking)
DOIs	https://doi.org/10.1111/exd.12445
Publication status	Published - 2014

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Prüßmann, J., Prüßmann, W., Recke, A., Rentzsch, K., Juhl, D., Henschler, R., Müller, S., Lamprecht, P., Schmidt, E., Csernok, E., Görg, S., Stöcker, W., Zillikens, D., Ibrahim, S. M., & Ludwig, R. J. (2014). Co-occurrence of autoantibodies in healthy blood donors. In Experimental Dermatology (pp. 519-521). (Experimental Dermatology; Vol. 23). Blackwell Publishing Ltd. https://doi.org/10.1111/exd.12445

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title = "Co-occurrence of autoantibodies in healthy blood donors",

abstract = "Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6,000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA positive compared to ANA negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens. This article is protected by copyright. All rights reserved.",

author = "Jasper Pr{\"u}{\ss}mann and Wiebke Pr{\"u}{\ss}mann and Andreas Recke and Kristin Rentzsch and David Juhl and Reinhard Henschler and Susen M{\"u}ller and Peter Lamprecht and Enno Schmidt and Elena Csernok and Siegfried G{\"o}rg and Winfried St{\"o}cker and Detlef Zillikens and Ibrahim, {Saleh M.} and Ludwig, {Ralf J.}",

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Prüßmann, J, Prüßmann, W, Recke, A, Rentzsch, K, Juhl, D, Henschler, R, Müller, S, Lamprecht, P , Schmidt, E, Csernok, E, Görg, S, Stöcker, W, Zillikens, D, Ibrahim, SM & Ludwig, RJ 2014, Co-occurrence of autoantibodies in healthy blood donors. in Experimental Dermatology. Experimental Dermatology, vol. 23, Blackwell Publishing Ltd, pp. 519-521. https://doi.org/10.1111/exd.12445

TY - CHAP

T1 - Co-occurrence of autoantibodies in healthy blood donors

AU - Prüßmann, Jasper

AU - Prüßmann, Wiebke

AU - Recke, Andreas

AU - Rentzsch, Kristin

AU - Juhl, David

AU - Henschler, Reinhard

AU - Müller, Susen

AU - Lamprecht, Peter

AU - Schmidt, Enno

AU - Csernok, Elena

AU - Görg, Siegfried

AU - Stöcker, Winfried

AU - Zillikens, Detlef

AU - Ibrahim, Saleh M.

AU - Ludwig, Ralf J.

PY - 2014

Y1 - 2014

N2 - Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6,000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA positive compared to ANA negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens. This article is protected by copyright. All rights reserved.

AB - Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6,000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA positive compared to ANA negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens. This article is protected by copyright. All rights reserved.

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DO - 10.1111/exd.12445

M3 - Chapter

C2 - 24816528

SN - 1600-0625 (Electronic)\r0906-6705 (Linking)

T3 - Experimental Dermatology

SP - 519

EP - 521

BT - Experimental Dermatology

PB - Blackwell Publishing Ltd

ER -

Co-occurrence of autoantibodies in healthy blood donors

Abstract

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