Co-occurrence of autoantibodies in healthy blood donors

Jasper Prüßmann, Wiebke Prüßmann, Andreas Recke, Kristin Rentzsch, David Juhl, Reinhard Henschler, Susen Müller, Peter Lamprecht, Enno Schmidt, Elena Csernok, Siegfried Görg, Winfried Stöcker, Detlef Zillikens, Saleh M. Ibrahim, Ralf J. Ludwig


Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6,000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA positive compared to ANA negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens. This article is protected by copyright. All rights reserved.
Original languageEnglish
Title of host publicationExperimental Dermatology
Number of pages3
PublisherBlackwell Publishing Ltd
Publication date2014
ISBN (Print)1600-0625 (Electronic)\r0906-6705 (Linking)
Publication statusPublished - 2014


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