Abstract
To enable the analysis of the regulation of the human cardiotrophin-1 gene expression, the 5'-flanking region of the human cardiotrophin-1 gene was cloned and sequenced. Data bank search revealed several cis-active DNA elements (SP1, CREB, C/EBP, AP1 and AP2 like and GATA) in the proximal 1.1 kb region. Six nested 5-'terminal deletion mutants from -1091/+39 to -218/+39 were fused to a luciferase reportergene and proved to be functionally active after transfection into COS-7 cells.
| Original language | English |
|---|---|
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 244 |
| Issue number | 2 |
| Pages (from-to) | 494-497 |
| Number of pages | 4 |
| ISSN | 0006-291X |
| DOIs | |
| Publication status | Published - 17.03.1998 |
Funding
This study was supported in part by a grant of the Verbund Klin-ische Pharmakologie Berlin/Brandenburg.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being -
SDG 5 Gender Equality
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